Magnetically-stimulated transformations in the nanostructure of PEGylated phytantriol-based nanoparticles for on-demand drug release

Xiaohan Sun, Joanne D. Du, Adrian Hawley, Angel Tan, Ben J. Boyd

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Lipid-based liquid crystalline (LLC) systems are formed by the self-assembly of lipid materials in aqueous environments. The internal nanostructures of LLC systems can be manipulated using remote stimuli and have the potential to serve as ‘on-demand’ drug delivery systems. In this study, a magnetically-responsive system that displayed a transition in nanostructure from liposomes to cubosomes/hexasomes under external alternating magnetic field (AMF) was established by the incorporation of iron oxide nanoparticles (IONPs) into a PEGylated phytantriol (PHYT)-based LLC system. Small angle X-ray scattering (SAXS) was utilized to assess the equilibrium phase behaviour of the systems with different compositions of the lipids to find the optimized formulation. Time-resolved SAXS was then used to determine the dynamic transformation of nanostructures of the IONP-containing systems with the activation of AMF. The formulation containing PHYT and DSPE-PEG2000 at a 95 to 5 molar percent ratio produced a transition from lamellar phase to bicontinuous cubic phase, showing a slow-to-fast drug release profile. Inclusion of either 5 nm or 15 nm IONPs imparted magnetic-responsiveness to the system. The magnetically-responsive system produced an ‘on-demand’ drug delivery system from which the drug release was able to be triggered externally by AMF-stimulation.

Original languageEnglish
Article number112005
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Volume207
DOIs
Publication statusPublished - Nov 2021

Keywords

  • Lipid-based formulation
  • Liquid crystalline nanostructure
  • Magnetically-activated
  • PEGylated liposomes
  • ‘On-demand’ drug release

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