Magnetic nanosystem a tool for targeted delivery and diagnostic application: Current challenges and recent advancement

Nilesh Rarokar, Sakshi Yadav, Suprit Saoji, Pratiksha Bramhe, Rishabh Agade, Shailendra Gurav, Pramod Khedekar, Vetriselvan Subramaniyan, Ling Shing Wong, Vinoth Kumarasamy

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Over the last two decades, researchers have paid more attention to magnetic nanosystems due to their wide application in diverse fields. The metal nanomaterials' antimicrobial and biocidal properties make them an essential nanosystem for biomedical applications. Moreover, the magnetic nanosystems could have also been used for diagnosis and treatment because of their magnetic, optical, and fluorescence properties. Superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) are the most widely used magnetic nanosystems prepared by a simple process. By surface modification, researchers have recently been working on conjugating metals like silica, copper, and gold with magnetic nanosystems. This hybridization of the nanosystems modifies the structural characteristics of the nanomaterials and helps to improve their efficacy for targeted drug and gene delivery. The hybridization of metals with various nanomaterials like micelles, cubosomes, liposomes, and polymeric nanomaterials is gaining more interest due to their nanometer size range and nontoxic, biocompatible nature. Moreover, they have good injectability and higher targeting ability by accumulation at the target site by application of an external magnetic field. The present article discussed the magnetic nanosystem in more detail regarding their structure, properties, interaction with the biological system, and diagnostic applications.

Original languageEnglish
Article number100231
Number of pages23
JournalInternational Journal of Pharmaceutics: X
Volume7
DOIs
Publication statusPublished - Jun 2024

Keywords

  • Biomedical applications
  • Magnetic nanoparticles
  • Magnetic properties

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