Magnesium-catalyzed hydroboration of pyridines

Merle Arrowsmith, Michael S Hill, Terrance Hadlington, Gabriele Kociok-Kohn, Catherine Weetman

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144 Citations (Scopus)

Abstract

Reaction of catalytic quantities of a beta-diketiminato n-butylmagnesium complex with pinacol-borane in the presence of pyridine derivatives provides facile access to borylated dihydropyridines. The reaction is applicable to a wide range of monocyclic and fused-ring pyridine derivatives and catalytic turnover is proposed to occur through a well-defined sequence of Mg-H/pyridine dearomatization and Mg-N/B-H sigma bond metathesis steps.
Original languageEnglish
Pages (from-to)5556 - 5559
Number of pages4
JournalOrganometallics
Volume30
Issue number21
DOIs
Publication statusPublished - 2011
Externally publishedYes

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