Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation

Ruvantha Ignatius Alexander Pinto, James Walter Godwin, Nadia Alicia Rosenthal

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Abstract

Macrophages are an immune cell type found in every organ of the body. Classically, macrophages are recognised as housekeeping cells involved in the detection of foreign antigens and danger signatures, and the clearance of tissue debris. However, macrophages are increasingly recognised as a highly versatile cell type with a diverse range of functions that are important for tissue homeostasis and injury responses. Recent research findings suggest that macrophages contribute to tissue regeneration and may play a role in the activation and mobilisation of stem cells. This review describes recent advances in our understanding of the role played by macrophages in cardiac tissue maintenance and repair following injury. We examine the involvement of exogenous and resident tissue macrophages in cardiac inflammatory responses and their potential activity in regulating cardiac regeneration.
Original languageEnglish
Pages (from-to)705 - 714
Number of pages10
JournalStem Cell Research
Volume13
Issue number3 (Part B)
DOIs
Publication statusPublished - 2014

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