Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 960 - 970 |
| Number of pages | 11 |
| Journal | Arthritis and Rheumatism |
| Volume | 63 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 |
Cite this
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Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice. / Santos, Leilani; Fan, Huapeng; Hall, Pamela; Ngo, Devi; Mackay, Charles; Fingerle-Rowson, Gunter; Bucala, Richard; Hickey, Michael; Morand, Eric.
In: Arthritis and Rheumatism, Vol. 63, No. 4, 2011, p. 960 - 970.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice
AU - Santos, Leilani
AU - Fan, Huapeng
AU - Hall, Pamela
AU - Ngo, Devi
AU - Mackay, Charles
AU - Fingerle-Rowson, Gunter
AU - Bucala, Richard
AU - Hickey, Michael
AU - Morand, Eric
PY - 2011
Y1 - 2011
N2 - Macrophage migration inhibitory factor (MIF) facilitates multiple aspects of inflammatory arthritis, the pathogenesis of which has been significantly linked to the activity of neutrophils. The effects of MIF on neutrophil recruitment are unknown. This study was undertaken to investigate the contribution of MIF to the regulation of neutrophil chemotactic responses. METHODS: K/BxN serum-transfer arthritis was induced in wild-type (WT), MIF(-/-) , and monocyte chemotactic protein 1 (MCP-1; CCL2)-deficient mice as well as in WT mice treated with monoclonal antibodies to cytokine-induced neutrophil chemoattractant (anti-KC). Leukocyte trafficking in vivo was examined using intravital microscopy, and neutrophil function in vitro was examined using migration chambers and assessment of MAP kinase activation.
AB - Macrophage migration inhibitory factor (MIF) facilitates multiple aspects of inflammatory arthritis, the pathogenesis of which has been significantly linked to the activity of neutrophils. The effects of MIF on neutrophil recruitment are unknown. This study was undertaken to investigate the contribution of MIF to the regulation of neutrophil chemotactic responses. METHODS: K/BxN serum-transfer arthritis was induced in wild-type (WT), MIF(-/-) , and monocyte chemotactic protein 1 (MCP-1; CCL2)-deficient mice as well as in WT mice treated with monoclonal antibodies to cytokine-induced neutrophil chemoattractant (anti-KC). Leukocyte trafficking in vivo was examined using intravital microscopy, and neutrophil function in vitro was examined using migration chambers and assessment of MAP kinase activation.
UR - http://onlinelibrary.wiley.com/doi/10.1002/art.30203/pdf
U2 - 10.1002/art.30203
DO - 10.1002/art.30203
M3 - Article
VL - 63
SP - 960
EP - 970
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
SN - 2326-5191
IS - 4
ER -