Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase

Huapeng Fan, Pamela Hall, Leilani Santos, Julia Louise Gregory, Gunter Fingerle-Rowson, Richard Bucala, Eric Morand, Michael Hickey

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68 Citations (Scopus)

Abstract

Macrophage migration inhibitory factor (MIF) promotes leukocyte recruitment to sites of inflammation. However, whether this stems from a direct effect on leukocyte migration is unknown. Furthermore, the role of the MIF-binding protein CD74 in this response has not been investigated. Therefore, the aim of this study was to examine the contributions of MIF and CD74 to chemokine-induced macrophage recruitment.
Original languageEnglish
Pages (from-to)4915 - 4924
Number of pages10
JournalJournal of Immunology
Volume186
Issue number8
DOIs
Publication statusPublished - 2011

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