Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase

Huapeng Fan, Pamela Hall, Leilani Santos, Julia Louise Gregory, Gunter Fingerle-Rowson, Richard Bucala, Eric Morand, Michael Hickey

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Macrophage migration inhibitory factor (MIF) promotes leukocyte recruitment to sites of inflammation. However, whether this stems from a direct effect on leukocyte migration is unknown. Furthermore, the role of the MIF-binding protein CD74 in this response has not been investigated. Therefore, the aim of this study was to examine the contributions of MIF and CD74 to chemokine-induced macrophage recruitment.
Original languageEnglish
Pages (from-to)4915 - 4924
Number of pages10
JournalJournal of Immunology
Volume186
Issue number8
DOIs
Publication statusPublished - 2011

Cite this

Fan, Huapeng ; Hall, Pamela ; Santos, Leilani ; Gregory, Julia Louise ; Fingerle-Rowson, Gunter ; Bucala, Richard ; Morand, Eric ; Hickey, Michael. / Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase. In: Journal of Immunology. 2011 ; Vol. 186, No. 8. pp. 4915 - 4924.
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abstract = "Macrophage migration inhibitory factor (MIF) promotes leukocyte recruitment to sites of inflammation. However, whether this stems from a direct effect on leukocyte migration is unknown. Furthermore, the role of the MIF-binding protein CD74 in this response has not been investigated. Therefore, the aim of this study was to examine the contributions of MIF and CD74 to chemokine-induced macrophage recruitment.",
author = "Huapeng Fan and Pamela Hall and Leilani Santos and Gregory, {Julia Louise} and Gunter Fingerle-Rowson and Richard Bucala and Eric Morand and Michael Hickey",
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Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase. / Fan, Huapeng; Hall, Pamela; Santos, Leilani; Gregory, Julia Louise; Fingerle-Rowson, Gunter; Bucala, Richard; Morand, Eric; Hickey, Michael.

In: Journal of Immunology, Vol. 186, No. 8, 2011, p. 4915 - 4924.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Fan, Huapeng

AU - Hall, Pamela

AU - Santos, Leilani

AU - Gregory, Julia Louise

AU - Fingerle-Rowson, Gunter

AU - Bucala, Richard

AU - Morand, Eric

AU - Hickey, Michael

PY - 2011

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AB - Macrophage migration inhibitory factor (MIF) promotes leukocyte recruitment to sites of inflammation. However, whether this stems from a direct effect on leukocyte migration is unknown. Furthermore, the role of the MIF-binding protein CD74 in this response has not been investigated. Therefore, the aim of this study was to examine the contributions of MIF and CD74 to chemokine-induced macrophage recruitment.

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U2 - 10.4049/jimmunol.1003713

DO - 10.4049/jimmunol.1003713

M3 - Article

VL - 186

SP - 4915

EP - 4924

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

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