Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets

Laurence Macia, Vicky Wang-Wei Tsai, Amy D Nguyen, Heiko Johnen, Tamara Kuffner, Yan-Chuan Shi, Shu Lin, Herbert Herzog, David A Brown, Samuel N Breit, Amanda Sainsbury

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    Abstract

    Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in cancer, provides protection against the development of obesity. Both under a normal chow diet and an obesogenic diet, the transgenic overexpression of MIC-1/GDF15 in mice leads to decreased body weight and fat mass. This lean phenotype was associated with decreased spontaneous but not fasting-induced food intake, on a background of unaltered energy expenditure and reduced physical activity. Importantly, the overexpression of MIC-1/GDF15 improved glucose tolerance, both under normal and high fat-fed conditions. Altogether, this work shows that the molecule MIC-1/GDF15 might be beneficial for the treatment of obesity as well as perturbations in glucose homeostasis.
    Original languageEnglish
    Article numbere34868
    Number of pages8
    JournalPLoS ONE
    Volume7
    Issue number4
    DOIs
    Publication statusPublished - 2012

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