Macrophage heterogeneity and renin-angiotensin system disorders

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Abstract

Macrophages are heterogeneous innate immune cells which are important in both the maintenance of tissue homeostasis and its disruption, by promoting tissue inflammation and fibrosis. The renin-angiotensin system is central to the pathophysiology of a large suite of diseases, which are driven in part by large amounts of tissue inflammation and fibrosis. Here, we review recent advances in understanding macrophage heterogeneity in origin and function, and how these may lead to new insights into the pathogenesis of these chronic diseases.

Original languageEnglish
Pages (from-to)445-454
Number of pages10
JournalPflugers Archiv European Journal of Physiology
Volume469
Issue number3-4
DOIs
Publication statusPublished - 1 Apr 2017

Keywords

  • Fibrosis
  • Hypertension
  • Inflammation
  • Monocyte
  • Tissue resident macrophage

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