Macrophage diversity in renal injury and repair

Sharon Denise Ricardo, Harry Van Goor, Allison A Eddy

    Research output: Contribution to journalArticleResearchpeer-review

    512 Citations (Scopus)

    Abstract

    Monocyte-derived macrophages can determine the outcome of the immune response and whether this response contributes to tissue repair or mediates tissue destruction. In addition to their important role in immune-mediated renal disease and host defense, macrophages play a fundamental role in tissue remodeling during embryonic development, acquired kidney disease, and renal allograft responses. This review summarizes macrophage phenotype and function in the orchestration of kidney repair and replacement of specialized renal cells following injury. Recent advances in our understanding of macrophage heterogeneity in response to their microenvironment raise new and exciting therapeutic possibilities to attenuate or conceivably reverse progressive renal disease in the context of fibrosis. Furthermore, parallels with pathological processes in many other organs also exist.
    Original languageEnglish
    Pages (from-to)3522 - 3530
    Number of pages9
    JournalJournal of Clinical Investigation
    Volume118
    Issue number11
    DOIs
    Publication statusPublished - 2008

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