Machine learning for predicting epileptic seizures using EEG signals: a review

Khansa Rasheed, Adnan Qayyum, Junaid Qadir, Shobi Sivathamboo, Patrick Kwan, Levin Kuhlmann, Terence O'Brien, Adeel Razi

Research output: Contribution to journalArticleResearchpeer-review

138 Citations (Scopus)


With the advancement in artificial intelligence (AI) and machine learning (ML) techniques, researchers are striving towards employing these techniques for advancing clinical practice. One of the key objectives in healthcare is the early detection and prediction of disease to timely provide preventive interventions. This is especially the case for epilepsy, which is characterized by recurrent and unpredictable seizures. Patients can be relieved from the adverse consequences of epileptic seizures if it could somehow be predicted in advance. Despite decades of research, seizure prediction remains an unsolved problem. This is likely to remain at least partly because of the inadequate amount of data to resolve the problem. There have been exciting new developments in ML-based algorithms that have the potential to deliver a paradigm shift in the early and accurate prediction of epileptic seizures. Here we provide a comprehensive review of state-of-the-art ML techniques in early prediction of seizures using EEG signals. We will identify the gaps, challenges, and pitfalls in the current research and recommend future directions.

Original languageEnglish
Pages (from-to)139-155
Number of pages17
JournalIEEE Reviews in Biomedical Engineering
Publication statusPublished - 2021


  • EEG
  • Epileptic Seizure
  • Machine Learning

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