Lyn, lupus, and (B) lymphocytes, a lesson on the critical balance of kinase signaling in immunity

Research output: Contribution to journalReview ArticleResearchpeer-review

31 Citations (Scopus)


Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as such represent an attractive therapeutic target. Lyn is a Src family tyrosine kinase that plays a major role in regulating signaling pathways within B cells as well as other hematopoietic cells. Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn-/- mice developing an SLE-like disease with plasma cell hyperplasia, underscoring the importance of tightly regulating signaling within B cells. This review highlights recent advances in our understanding of the function of the Src family tyrosine kinase Lyn in B lymphocytes and its contribution to positive and negative signaling pathways that are dysregulated in autoimmunity.

Original languageEnglish
Article number401
Number of pages10
JournalFrontiers in Immunology
Issue numberMAR
Publication statusPublished - 1 Mar 2018


  • Autoimmunity
  • B cell
  • B-cell receptor
  • Cell signaling
  • Lupus
  • Lyn
  • SFK
  • Systemic lupus erythematosus

Cite this