Lyn, lupus, and (B) lymphocytes, a lesson on the critical balance of kinase signaling in immunity

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Abstract

Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation. B cells have been implicated in disease progression and as such represent an attractive therapeutic target. Lyn is a Src family tyrosine kinase that plays a major role in regulating signaling pathways within B cells as well as other hematopoietic cells. Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn-/- mice developing an SLE-like disease with plasma cell hyperplasia, underscoring the importance of tightly regulating signaling within B cells. This review highlights recent advances in our understanding of the function of the Src family tyrosine kinase Lyn in B lymphocytes and its contribution to positive and negative signaling pathways that are dysregulated in autoimmunity.

Original languageEnglish
Article number401
Number of pages10
JournalFrontiers in Immunology
Volume9
Issue numberMAR
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • Autoimmunity
  • B cell
  • B-cell receptor
  • Cell signaling
  • Lupus
  • Lyn
  • SFK
  • Systemic lupus erythematosus

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