Lymphovascular and neural regulation of metastasis: Shared tumour signalling pathways and novel therapeutic approaches

Caroline Phuong Le; Tara Karnezis; Marc G Achen; Steven A Stacker; Erica Kate Sloan

doi:10.1016/j.bpa.2013.10.008

Lymphovascular and neural regulation of metastasis: Shared tumour signalling pathways and novel therapeutic approaches

Caroline Phuong Le, Tara Karnezis, Marc G Achen, Steven A Stacker, Erica Kate Sloan

Drug Discovery Biology

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

The progression of cancer is supported by a wide variety of non-neoplastic cell types which make up the tumour stroma, including immune cells, endothelial cells, cancer-associated fibroblasts and nerve fibres. These host cells contribute molecular signals that enhance primary tumour growth and provide physical avenues for metastatic dissemination. This article provides an overview of the role of blood vessels, lymphatic vessels and nerve fibres in the tumour microenvironment and highlights the interconnected molecular signalling pathways that control their development and activation in cancer. Further, this article highlights the known pharmacological agents which target these pathways and discusses the potential therapeutic uses of drugs that target angiogenesis, lymphangiogenesis and stress-response pathways in the different stages of cancer care.

Original language	English
Pages (from-to)	409 - 425
Number of pages	17
Journal	Bailliere's Best Practice and Research in Clinical Anaesthesiology
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.bpa.2013.10.008
Publication status	Published - 2013

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10.1016/j.bpa.2013.10.008

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Cite this

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title = "Lymphovascular and neural regulation of metastasis: Shared tumour signalling pathways and novel therapeutic approaches",

abstract = "The progression of cancer is supported by a wide variety of non-neoplastic cell types which make up the tumour stroma, including immune cells, endothelial cells, cancer-associated fibroblasts and nerve fibres. These host cells contribute molecular signals that enhance primary tumour growth and provide physical avenues for metastatic dissemination. This article provides an overview of the role of blood vessels, lymphatic vessels and nerve fibres in the tumour microenvironment and highlights the interconnected molecular signalling pathways that control their development and activation in cancer. Further, this article highlights the known pharmacological agents which target these pathways and discusses the potential therapeutic uses of drugs that target angiogenesis, lymphangiogenesis and stress-response pathways in the different stages of cancer care.",

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Lymphovascular and neural regulation of metastasis: Shared tumour signalling pathways and novel therapeutic approaches. / Le, Caroline Phuong; Karnezis, Tara; Achen, Marc G; Stacker, Steven A; Sloan, Erica Kate.

In: Bailliere's Best Practice and Research in Clinical Anaesthesiology, Vol. 27, No. 4, 2013, p. 409 - 425.

Research output: Contribution to journal › Article › Research › peer-review

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