TY - JOUR
T1 - Lymphovascular and neural regulation of metastasis: Shared tumour signalling pathways and novel therapeutic approaches
AU - Le, Caroline Phuong
AU - Karnezis, Tara
AU - Achen, Marc G
AU - Stacker, Steven A
AU - Sloan, Erica Kate
PY - 2013
Y1 - 2013
N2 - The progression of cancer is supported by a wide variety of non-neoplastic cell types which make up the tumour stroma, including immune cells, endothelial cells, cancer-associated fibroblasts and nerve fibres. These host cells contribute molecular signals that enhance primary tumour growth and provide physical avenues for metastatic dissemination. This article provides an overview of the role of blood vessels, lymphatic vessels and nerve fibres in the tumour microenvironment and highlights the interconnected molecular signalling pathways that control their development and activation in cancer. Further, this article highlights the known pharmacological agents which target these pathways and discusses the potential therapeutic uses of drugs that target angiogenesis, lymphangiogenesis and stress-response pathways in the different stages of cancer care.
AB - The progression of cancer is supported by a wide variety of non-neoplastic cell types which make up the tumour stroma, including immune cells, endothelial cells, cancer-associated fibroblasts and nerve fibres. These host cells contribute molecular signals that enhance primary tumour growth and provide physical avenues for metastatic dissemination. This article provides an overview of the role of blood vessels, lymphatic vessels and nerve fibres in the tumour microenvironment and highlights the interconnected molecular signalling pathways that control their development and activation in cancer. Further, this article highlights the known pharmacological agents which target these pathways and discusses the potential therapeutic uses of drugs that target angiogenesis, lymphangiogenesis and stress-response pathways in the different stages of cancer care.
UR - http://tinyurl.com/nxnjy2o
U2 - 10.1016/j.bpa.2013.10.008
DO - 10.1016/j.bpa.2013.10.008
M3 - Article
VL - 27
SP - 409
EP - 425
JO - Bailliere's Best Practice and Research in Clinical Anaesthesiology
JF - Bailliere's Best Practice and Research in Clinical Anaesthesiology
SN - 1521-6896
IS - 4
ER -