Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection

Lalit Kumar Dubey, Luc Lebon, Ilaria Mosconi, Chen Ying Yang, Elke Scandella, Burkhard Ludewig, Sanjiv A. Luther, Nicola L. Harris

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25 Citations (Scopus)

Abstract

Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought to be restricted to the postnatal period, we observed that the draining mesenteric lymph nodes (mLN) of helminth-infected mice form an extensive number of new, centrally located, B cell follicles in response to IL-4Rα-dependent inflammation. IL-4Rα signaling promoted LTα1β2 (lymphotoxin) expression by B cells, which then interacted with CCL19 positive stromal cells to promote lymphoid enlargement and the formation of germinal center containing B cell follicles. Importantly, de novo follicle formation functioned to promote both total and parasite-specific antibody production. These data reveal a role for type 2 inflammation in promoting stromal cell remodeling and de novo follicle formation by promoting B cell-stromal cell crosstalk.

Original languageEnglish
Pages (from-to)1527-1541
Number of pages15
JournalCell Reports
Volume15
Issue number7
DOIs
Publication statusPublished - 17 May 2016
Externally publishedYes

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