The effect of relatively low benzene concentrations on risks of specific lymphohaematopoietic cancer subtypes was studied. Three nested case-control studies among petroleum workers in Australia, Canada, and the UK were updated and pooled to provide greater precision. Updates identified 170 additional cases giving a total of 370, sufficient for separate analyses by leukaemia subtypes, myelodysplastic syndrome (MDS), and myeloproliferative disease (MPD). Risks for acute myeloid leukemia (AML) tended to increase as categorical benzene exposure increased when pooling the original data from the previously published studies using both the original and revised exposure assessment. Dose-response esults from the updated pooled data for MDS, MPD, AML and chronic myeloid leukemia, and chronic lymphoid leukemia were presented from the updated dataset.
|Number of pages||1|
|Publication status||Published - Sep 2011|