TY - JOUR
T1 - Lymphocyte count in peripheral blood is not associated with the level of clinical response to treatment with fingolimod
AU - Fragoso, Yara Dadalti
AU - Spelman, Tim
AU - Boz, Cavit
AU - Alroughani, Raed
AU - Lugaresi, Alessandra
AU - Vucic, Steve
AU - Butzkueven, Helmut
AU - Terzi, Murat
AU - Havrdova, Eva
AU - Horakova, Dana
AU - Granella, Franco
AU - Olascoaga, Javier
AU - Sánchez-Menoyo, José Luis
AU - Pucci, Eugenio
AU - Barnett, Michael
AU - Brooks, Joseph Bruno B.
AU - Haartsen, Jodi
AU - on behalf of the Lymphopenia and Efficacy of Fingolimod MSBase sub-study Investigators
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background Fingolimod is an efficient and safe drug for treating relapsing-remitting multiple sclerosis (RRMS). In vivo, fingolimod is phosphorylated and binds to “sphingosine-1-phosphate”(S1P) receptors that are expressed in a wide range of cells, including lymphocytes. Under the effect of fingolimod, lymphocytes are retained in lymphoid tissues through the regulation of S1P1 receptors. The aim of the present study was to assess whether the degree of lymphopenia was correlated to the positive treatment response of RRMS patients with fingolimod. Methods Data was sourced from the MSBase Registry. Patients were divided into two groups, according to the lymphocyte count on peripheral blood examination. Annualized Relapse Rate (ARR), time to first relapse and time to six-month confirmed disability progression were compared between groups. Results Group one consisted of 202 patients who reached 750 lymphocytes/mm3 during treatment while the comparison group two included 101 patients who never reached less than 1000 lymphocytes/mm3 in peripheral blood during the observation period. There were no differences between groups in ARR, time to first relapse or time to six-month confirmed disability progression. Conclusion The degree of lymphopenia in peripheral blood was not associated to the positive treatment response of fingolimod in RRMS patients.
AB - Background Fingolimod is an efficient and safe drug for treating relapsing-remitting multiple sclerosis (RRMS). In vivo, fingolimod is phosphorylated and binds to “sphingosine-1-phosphate”(S1P) receptors that are expressed in a wide range of cells, including lymphocytes. Under the effect of fingolimod, lymphocytes are retained in lymphoid tissues through the regulation of S1P1 receptors. The aim of the present study was to assess whether the degree of lymphopenia was correlated to the positive treatment response of RRMS patients with fingolimod. Methods Data was sourced from the MSBase Registry. Patients were divided into two groups, according to the lymphocyte count on peripheral blood examination. Annualized Relapse Rate (ARR), time to first relapse and time to six-month confirmed disability progression were compared between groups. Results Group one consisted of 202 patients who reached 750 lymphocytes/mm3 during treatment while the comparison group two included 101 patients who never reached less than 1000 lymphocytes/mm3 in peripheral blood during the observation period. There were no differences between groups in ARR, time to first relapse or time to six-month confirmed disability progression. Conclusion The degree of lymphopenia in peripheral blood was not associated to the positive treatment response of fingolimod in RRMS patients.
KW - Disability
KW - Fingolimod
KW - Lymphocytes
KW - Multiple sclerosis
KW - Relapses
UR - http://www.scopus.com/inward/record.url?scp=85034851540&partnerID=8YFLogxK
U2 - 10.1016/j.msard.2017.11.018
DO - 10.1016/j.msard.2017.11.018
M3 - Article
C2 - 29182993
AN - SCOPUS:85034851540
SN - 2211-0348
VL - 19
SP - 105
EP - 108
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
ER -