Lymphatic transport of proteins after subcutaneous administration

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Abstract

This mini-review summarizes the relevant literature regarding the lymphatic transport of proteins after subcutaneous administration. A review of the physiology of the lymphatics and inherent anatomical differences between blood and lymph capillaries is presented followed by a brief overview of the general characteristics of protein absorption and bioavailability following S.C. injection. A description of factors known to directly affect the lymphatic uptake of macromolecules follows and is supported by representative data from this laboratory. A brief perspective on the importance of lymphatic uptake and transport in understanding the biopharmaceutical properties of protein drugs and potentially targeting the lymphatics is presented. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)297-310
Number of pages14
JournalJournal of Pharmaceutical Sciences
Volume89
Issue number3
DOIs
Publication statusPublished - Mar 2000

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