Lymph node homing of T cells and dendritic cells via afferent lymphatics

Reinhold Förster, Asolina Braun, Tim Worbs

Research output: Contribution to journalReview ArticleResearchpeer-review

128 Citations (Scopus)

Abstract

The continuous migration of immune cells is of utmost importance for the induction of both protective immunity as well as immunological tolerance. However, relatively little is known about the molecular cues that regulate the entry of immune cells from peripheral, nonlymphoid tissues into afferent lymph vessels and, in particular, their subsequent transmigration from afferent lymphatics into the parenchyma of draining lymph nodes (LNs). Here, we review the requirements for T cells and dendritic cells (DCs) to enter initial afferent lymph vessels of the skin. We discuss how these cells subsequently gain access to the paracortex of draining lymph nodes; a location that allows for efficient interaction between both cell populations, providing the right environment for the induction of immunity as well as tolerance.

Original languageEnglish
Pages (from-to)271-280
Number of pages10
JournalTrends in Immunology
Volume33
Issue number6
DOIs
Publication statusPublished - 1 Jun 2012
Externally publishedYes

Keywords

  • Afferent lymph
  • Dendritic cells
  • Homing
  • Lymph node architecture
  • T cells

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