TY - JOUR
T1 - Lutein
T2 - A comprehensive review on its chemical, biological activities and therapeutic potentials
AU - Fuad, Nurul Iman Nurul
AU - Sekar, Mahendran
AU - Gan, Siew Hua
AU - Lum, Pei Teng
AU - Vaijanathappa, Jaishree
AU - Ravi, Subban
N1 - Publisher Copyright:
© 2020 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - Background: Lutein is a naturally occurring carotenoid found in high amounts in flowers, grains, fruits and green vegetables with green leaves include spinach, kale and carrots. The market for lutein encompasses pharmaceutical, dietary supplement, food, animal and fish feed industries. Objective: The present review aimed to provide an updated and comprehensive analysis of lutein, including its chemistry, biological properties and therapeutic potentials. Methods: Relevant literatures were collected from several scientific databases, include Google Scholar, Pubmed and ScienceDirect between 2000 to till date. Following a detailed inclusion and exclusion screening process, the information obtained was summarized. Results: Information on the sources, chemistry and biological properties including antioxidant, anti-arthrisits, anti-inflammatory, hepatoprotective, cardioprotective, anti-cataract, antidiabetic, anticancer and bone remodelling activities, as well as food industry processing for lutein were tabled. Lutein can be considered powerful antioxidants along with multifaceted molecular targets, such as NF-ҡB, PI3K/Akt, Nrf-2, HO-1 and SIRT-1 signaling pathways in various pathological conditions. Conclusion: The present review observe the chemical, pharmacological properties, in addition to the therapeutic potentials of lutein. It is hoped that the information can provide a good reference to aid in the development and utilization of lutein in phytopharmaceuticals and food industries.
AB - Background: Lutein is a naturally occurring carotenoid found in high amounts in flowers, grains, fruits and green vegetables with green leaves include spinach, kale and carrots. The market for lutein encompasses pharmaceutical, dietary supplement, food, animal and fish feed industries. Objective: The present review aimed to provide an updated and comprehensive analysis of lutein, including its chemistry, biological properties and therapeutic potentials. Methods: Relevant literatures were collected from several scientific databases, include Google Scholar, Pubmed and ScienceDirect between 2000 to till date. Following a detailed inclusion and exclusion screening process, the information obtained was summarized. Results: Information on the sources, chemistry and biological properties including antioxidant, anti-arthrisits, anti-inflammatory, hepatoprotective, cardioprotective, anti-cataract, antidiabetic, anticancer and bone remodelling activities, as well as food industry processing for lutein were tabled. Lutein can be considered powerful antioxidants along with multifaceted molecular targets, such as NF-ҡB, PI3K/Akt, Nrf-2, HO-1 and SIRT-1 signaling pathways in various pathological conditions. Conclusion: The present review observe the chemical, pharmacological properties, in addition to the therapeutic potentials of lutein. It is hoped that the information can provide a good reference to aid in the development and utilization of lutein in phytopharmaceuticals and food industries.
KW - Antioxidant
KW - Inflammatory cytokines
KW - Lutein
KW - Molecular targets
KW - Pharmacology
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=85096377719&partnerID=8YFLogxK
U2 - 10.5530/pj.2020.12.239
DO - 10.5530/pj.2020.12.239
M3 - Review Article
AN - SCOPUS:85096377719
SN - 0975-3575
VL - 12
SP - 1769
EP - 1778
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 6 Suppl.
ER -