Lung Diseases

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Inflammasomes are large innate cytoplasmic complexes that play a major role in promoting inflammation in the lung in response to a range of environmental and infectious stimuli. Inflammasomes are critical for driving acute innate immune responses that resolve infection and maintain tissue homeostasis. However, dysregulated or excessive inflammasome activation can be detrimental. Here, we discuss the plethora of recent data from clinical studies and small animal disease models that implicate excessive inflammasome responses in the pathogenesis of a number of acute and chronic respiratory inflammatory diseases. Understanding of the role of inflammasomes in lung disease is of great therapeutic interest.

Original languageEnglish
Title of host publicationInflammasomes
Subtitle of host publicationClinical and Therapeutic Implications
EditorsMario D. Cordero, Elísabet Alcocer-Gómez
Place of PublicationCham, Switzerland
PublisherSpringer
Chapter4
Pages61-84
Number of pages24
Volume108
ISBN (Electronic) 9783319893907
ISBN (Print)9783319893891
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameExperientia Supplementum
Volume108
ISSN (Print)1664-431X
ISSN (Electronic)2504-3692

Keywords

  • Disease pathogenesis
  • Inflammasomes
  • Inflammation
  • Lung disease

Cite this

Ruwanpura, S., Rosli, S., & Tate, M. (2018). Lung Diseases. In M. D. Cordero, & E. Alcocer-Gómez (Eds.), Inflammasomes: Clinical and Therapeutic Implications (Vol. 108, pp. 61-84). (Experientia Supplementum; Vol. 108). Cham, Switzerland: Springer. https://doi.org/10.1007/978-3-319-89390-7_4
Ruwanpura, Saleela ; Rosli, Sarah ; Tate, Michelle. / Lung Diseases. Inflammasomes: Clinical and Therapeutic Implications. editor / Mario D. Cordero ; Elísabet Alcocer-Gómez. Vol. 108 Cham, Switzerland : Springer, 2018. pp. 61-84 (Experientia Supplementum).
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Ruwanpura, S, Rosli, S & Tate, M 2018, Lung Diseases. in MD Cordero & E Alcocer-Gómez (eds), Inflammasomes: Clinical and Therapeutic Implications. vol. 108, Experientia Supplementum, vol. 108, Springer, Cham, Switzerland, pp. 61-84. https://doi.org/10.1007/978-3-319-89390-7_4

Lung Diseases. / Ruwanpura, Saleela; Rosli, Sarah; Tate, Michelle.

Inflammasomes: Clinical and Therapeutic Implications. ed. / Mario D. Cordero; Elísabet Alcocer-Gómez. Vol. 108 Cham, Switzerland : Springer, 2018. p. 61-84 (Experientia Supplementum; Vol. 108).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

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AB - Inflammasomes are large innate cytoplasmic complexes that play a major role in promoting inflammation in the lung in response to a range of environmental and infectious stimuli. Inflammasomes are critical for driving acute innate immune responses that resolve infection and maintain tissue homeostasis. However, dysregulated or excessive inflammasome activation can be detrimental. Here, we discuss the plethora of recent data from clinical studies and small animal disease models that implicate excessive inflammasome responses in the pathogenesis of a number of acute and chronic respiratory inflammatory diseases. Understanding of the role of inflammasomes in lung disease is of great therapeutic interest.

KW - Disease pathogenesis

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Ruwanpura S, Rosli S, Tate M. Lung Diseases. In Cordero MD, Alcocer-Gómez E, editors, Inflammasomes: Clinical and Therapeutic Implications. Vol. 108. Cham, Switzerland: Springer. 2018. p. 61-84. (Experientia Supplementum). https://doi.org/10.1007/978-3-319-89390-7_4