Lung diffusing capacity in adult bronchiectasis: A longitudinal study

Paul King, Stephen Holdsworth, Nick Freezer, Elmer Virgil Villanueva, Michael Farmer, Paul Guy, Peter Holmes

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Recent studies described a progressive decline in lung volumes in adult bronchiectasis. Interstitial lung disease is also a feature of bronchiectasis, but whether this is associated with a decline in lung diffusing capacity (measured as the diffusing capacity of the lung for carbon monoxide [D(LCO)]) is not well known. OBJECTIVE: To assess longitudinal decline in diffusing capacity of the lung for carbon monoxide (D(LCO)) in adult bronchiectasis. METHODS: Sixty-one subjects had a detailed baseline clinical and laboratory assessment, then were followed regularly with clinical and lung-function assessment for a median 7 years.
Original languageEnglish
Pages (from-to)1686 - 1692
Number of pages7
JournalRespiratory Care
Issue number12
Publication statusPublished - 2010

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