Luminal Cells Are Favored as the Cell of Origin for Prostate Cancer

Zhu A. Wang, Roxanne Toivanen, Sarah K. Bergren, Pierre Chambon, Michael M Shen

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The identification of cell types of origin for cancer has important implications for tumor stratification and personalized treatment. For prostate cancer, the cell of origin has been intensively studied, but it has remained unclear whether basal or luminal epithelial cells, or both, represent cells of origin under physiological conditions invivo. Here, we use a novel lineage-tracing strategy to assess the cell of origin in a diverse range of mouse models, including Nkx3.1+/-; Pten+/-, Pten+/-, Hi-Myc, and TRAMP mice, as well as a hormonal carcinogenesis model. Our results show that luminal cells are consistently the observed cell of origin for each model insitu; however, explanted basal cells from these mice can generate tumors in grafts. Consequently, we propose that luminal cells are favored as cells of origin in many contexts, whereas basal cells only give rise to tumorsafter differentiation into luminal cells.

Original languageEnglish
Pages (from-to)1339-1346
Number of pages8
JournalCell Reports
Volume8
Issue number5
DOIs
Publication statusPublished - 2014
Externally publishedYes

Cite this

Wang, Zhu A. ; Toivanen, Roxanne ; Bergren, Sarah K. ; Chambon, Pierre ; Shen, Michael M. / Luminal Cells Are Favored as the Cell of Origin for Prostate Cancer. In: Cell Reports. 2014 ; Vol. 8, No. 5. pp. 1339-1346.
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Luminal Cells Are Favored as the Cell of Origin for Prostate Cancer. / Wang, Zhu A.; Toivanen, Roxanne; Bergren, Sarah K.; Chambon, Pierre; Shen, Michael M.

In: Cell Reports, Vol. 8, No. 5, 2014, p. 1339-1346.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Chambon, Pierre

AU - Shen, Michael M

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