TY - JOUR
T1 - Lubricin: a versatile, biological anti-adhesive with properties comparable to polyethylene glycol
AU - Greene, George Wren
AU - Martin, Lisandra Lorraine
AU - Tabor, Richard Francis
AU - Michalczyk, Agnes
AU - Ackland, Leigh M
AU - Horn, Roger
PY - 2015
Y1 - 2015
N2 - Lubricin is a glycoprotein found in articular joints which has been recognized as being an important biological boundary lubricant molecule. Besides providing lubrication, we demonstrate, using a quartz crystal microbalance, that lubricin also exhibits anti-adhesive properties and is highly effective at preventing the non-specific adsorption of representative globular proteins and constituents of blood plasma. This impressive anti-adhesive property, combined with lubricin s ability to readily self-assemble to form dense, highly stable telechelic polymer brush layers on virtually any substrates, and its innate biocompatibility, makes it an attractive candidate for anti-adhesive and anti-fouling coatings. We show that coatings of lubricin protein are as effective as, or better than, self-assembled monolayers of polyethylene glycol over a wide range of pH and that this provides a simple, versatile, highly stable, and highly effective method of controlling unwanted adhesion to surfaces.
AB - Lubricin is a glycoprotein found in articular joints which has been recognized as being an important biological boundary lubricant molecule. Besides providing lubrication, we demonstrate, using a quartz crystal microbalance, that lubricin also exhibits anti-adhesive properties and is highly effective at preventing the non-specific adsorption of representative globular proteins and constituents of blood plasma. This impressive anti-adhesive property, combined with lubricin s ability to readily self-assemble to form dense, highly stable telechelic polymer brush layers on virtually any substrates, and its innate biocompatibility, makes it an attractive candidate for anti-adhesive and anti-fouling coatings. We show that coatings of lubricin protein are as effective as, or better than, self-assembled monolayers of polyethylene glycol over a wide range of pH and that this provides a simple, versatile, highly stable, and highly effective method of controlling unwanted adhesion to surfaces.
UR - http://tinyurl.com/kdu3shv
U2 - 10.1016/j.biomaterials.2015.02.086
DO - 10.1016/j.biomaterials.2015.02.086
M3 - Article
VL - 53
SP - 127
EP - 136
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
ER -