TY - JOUR
T1 - Lower serum testosterone concentrations are associated with a higher incidence of dementia in men
T2 - The UK Biobank prospective cohort study
AU - Marriott, Ross J.
AU - Murray, Kevin
AU - Flicker, Leon
AU - Hankey, Graeme J.
AU - Matsumoto, Alvin M.
AU - Dwivedi, Girish
AU - Antonio, Leen
AU - Almeida, Osvaldo P.
AU - Bhasin, Shalender
AU - Dobs, Adrian S.
AU - Handelsman, David J.
AU - Haring, Robin
AU - O'Neill, Terence W.
AU - Ohlsson, Claes
AU - Orwoll, Eric S.
AU - Vanderschueren, Dirk
AU - Wittert, Gary A.
AU - Wu, Frederick C.W.
AU - Yeap, Bu B.
N1 - Funding Information:
This work was supported by the Western Australian Health Translation Network and the Australian Government's Medical Research Future Fund via the Rapid Applied Research Translation program; and by a philanthropic donation from Lawley Pharmaceuticals to the University of Western Australia. The funding bodies had no role in the conduct of the research.
Funding Information:
BBY and RJM received funding support for the present manuscript from the Western Australian Health Translation Network and the Australian Government's Medical Research Future Fund, and via a philanthropic donation by Lawley Pharmaceuticals to the University of Western Australia. All other authors report no disclosures related to the present manuscript. A full list of disclosures unrelated to the present manuscript for all authors within the past 36 months is provided (Supplementary Material).
Publisher Copyright:
© 2021 the Alzheimer's Association
PY - 2022/10
Y1 - 2022/10
N2 - Introduction: The association of testosterone concentrations with dementia risk remains uncertain. We examined associations of serum testosterone and sex hormone–binding globulin (SHBG) with incidence of dementia and Alzheimer's disease. Methods: Serum total testosterone and SHBG were measured by immunoassay. The incidence of dementia and Alzheimer's disease (AD) was recorded. Cox proportional hazards regression was adjusted for age and other variables. Results: In 159,411 community-dwelling men (median age 61, followed for 7 years), 826 developed dementia, including 288 from AD. Lower total testosterone was associated with a higher incidence of dementia (overall trend: P =.001, lowest vs highest quintile: hazard ratio [HR] = 1.43, 95% confidence interval [CI] = 1.13-1.81), and AD (P =.017, HR = 1.80, CI = 1.21-2.66). Lower SHBG was associated with a lower incidence of dementia (P <.001, HR = 0.66, CI = 0.51-0.85) and AD (P =.012, HR = 0.53, CI = 0.34-0.84). Discussion: Lower total testosterone and higher SHBG are independently associated with incident dementia and AD in older men. Additional research is needed to determine causality.
AB - Introduction: The association of testosterone concentrations with dementia risk remains uncertain. We examined associations of serum testosterone and sex hormone–binding globulin (SHBG) with incidence of dementia and Alzheimer's disease. Methods: Serum total testosterone and SHBG were measured by immunoassay. The incidence of dementia and Alzheimer's disease (AD) was recorded. Cox proportional hazards regression was adjusted for age and other variables. Results: In 159,411 community-dwelling men (median age 61, followed for 7 years), 826 developed dementia, including 288 from AD. Lower total testosterone was associated with a higher incidence of dementia (overall trend: P =.001, lowest vs highest quintile: hazard ratio [HR] = 1.43, 95% confidence interval [CI] = 1.13-1.81), and AD (P =.017, HR = 1.80, CI = 1.21-2.66). Lower SHBG was associated with a lower incidence of dementia (P <.001, HR = 0.66, CI = 0.51-0.85) and AD (P =.012, HR = 0.53, CI = 0.34-0.84). Discussion: Lower total testosterone and higher SHBG are independently associated with incident dementia and AD in older men. Additional research is needed to determine causality.
UR - http://www.scopus.com/inward/record.url?scp=85122155181&partnerID=8YFLogxK
U2 - 10.1002/alz.12529
DO - 10.1002/alz.12529
M3 - Article
C2 - 34978125
AN - SCOPUS:85122155181
SN - 1552-5260
VL - 18
SP - 1907
EP - 1918
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
IS - 10
ER -
