Lower limb progressive resistance training improves leg strength but not gait speed or balance in Parkinson's disease

A systematic review and meta-analysis

Alex Tillman, Makii Muthalib, Ashlee M. Hendy, Liam G. Johnson, Timo Rantalainen, Dawson J. Kidgell, Peter G. Enticott, Wei Peng Teo

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)

Abstract

The use of progressive resistance training (PRT) to improve gait and balance in people with Parkinson's disease (PD) is an emerging area of interest. However, the main effects of PRT on lower limb functions such as gait, balance, and leg strength in people with PD remain unclear. Therefore, the aim of the meta-analysis is to evaluate the evidence surrounding the use of PRT to improve gait and balance in people with PD. Five electronic databases, from inception to December 2014, were searched to identify the relevant studies. Data extraction was performed by two independent reviewers and methodological quality was assessed using the PEDro scale. Standardized mean differences (SMD) and 95% confidence intervals (CIs) of fixed and random effects models were used to calculate the effect sizes between experimental and control groups and I2 statistics were used to determine levels of heterogeneity. In total, seven studies were identified consisting of 172 participants (experimental n = 84; control n = 88). The pooled results showed a moderate but significant effect of PRT on leg strength (SMD 1.42, 95% CI 0.464-2.376); however, no significant effects were observed for gait speed (SMD 0.418, 95% CI -0.219 to 1.055). No significant effects were observed for balance measures included in this review. In conclusion, our results showed no discernable effect of PRT on gait and balance measures, although this is likely due to the lack of studies available. It may be suggested that PRT be performed in conjunction with balance or task-specific functional training to elicit greater lower limb functional benefits in people with PD.

Original languageEnglish
Article number40
JournalFrontiers in Aging Neuroscience
Volume7
Issue numberMAR
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Balance
  • Gait speed
  • Leg strength
  • Parkinson's disease
  • Progressive resistance training

Cite this

@article{b9d398e670f84059b351518054239196,
title = "Lower limb progressive resistance training improves leg strength but not gait speed or balance in Parkinson's disease: A systematic review and meta-analysis",
abstract = "The use of progressive resistance training (PRT) to improve gait and balance in people with Parkinson's disease (PD) is an emerging area of interest. However, the main effects of PRT on lower limb functions such as gait, balance, and leg strength in people with PD remain unclear. Therefore, the aim of the meta-analysis is to evaluate the evidence surrounding the use of PRT to improve gait and balance in people with PD. Five electronic databases, from inception to December 2014, were searched to identify the relevant studies. Data extraction was performed by two independent reviewers and methodological quality was assessed using the PEDro scale. Standardized mean differences (SMD) and 95{\%} confidence intervals (CIs) of fixed and random effects models were used to calculate the effect sizes between experimental and control groups and I2 statistics were used to determine levels of heterogeneity. In total, seven studies were identified consisting of 172 participants (experimental n = 84; control n = 88). The pooled results showed a moderate but significant effect of PRT on leg strength (SMD 1.42, 95{\%} CI 0.464-2.376); however, no significant effects were observed for gait speed (SMD 0.418, 95{\%} CI -0.219 to 1.055). No significant effects were observed for balance measures included in this review. In conclusion, our results showed no discernable effect of PRT on gait and balance measures, although this is likely due to the lack of studies available. It may be suggested that PRT be performed in conjunction with balance or task-specific functional training to elicit greater lower limb functional benefits in people with PD.",
keywords = "Balance, Gait speed, Leg strength, Parkinson's disease, Progressive resistance training",
author = "Alex Tillman and Makii Muthalib and Hendy, {Ashlee M.} and Johnson, {Liam G.} and Timo Rantalainen and Kidgell, {Dawson J.} and Enticott, {Peter G.} and Teo, {Wei Peng}",
year = "2015",
month = "1",
day = "1",
doi = "10.3389/fnagi.2015.00040",
language = "English",
volume = "7",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Research Foundation",
number = "MAR",

}

Lower limb progressive resistance training improves leg strength but not gait speed or balance in Parkinson's disease : A systematic review and meta-analysis. / Tillman, Alex; Muthalib, Makii; Hendy, Ashlee M.; Johnson, Liam G.; Rantalainen, Timo; Kidgell, Dawson J.; Enticott, Peter G.; Teo, Wei Peng.

In: Frontiers in Aging Neuroscience, Vol. 7, No. MAR, 40, 01.01.2015.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Lower limb progressive resistance training improves leg strength but not gait speed or balance in Parkinson's disease

T2 - A systematic review and meta-analysis

AU - Tillman, Alex

AU - Muthalib, Makii

AU - Hendy, Ashlee M.

AU - Johnson, Liam G.

AU - Rantalainen, Timo

AU - Kidgell, Dawson J.

AU - Enticott, Peter G.

AU - Teo, Wei Peng

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The use of progressive resistance training (PRT) to improve gait and balance in people with Parkinson's disease (PD) is an emerging area of interest. However, the main effects of PRT on lower limb functions such as gait, balance, and leg strength in people with PD remain unclear. Therefore, the aim of the meta-analysis is to evaluate the evidence surrounding the use of PRT to improve gait and balance in people with PD. Five electronic databases, from inception to December 2014, were searched to identify the relevant studies. Data extraction was performed by two independent reviewers and methodological quality was assessed using the PEDro scale. Standardized mean differences (SMD) and 95% confidence intervals (CIs) of fixed and random effects models were used to calculate the effect sizes between experimental and control groups and I2 statistics were used to determine levels of heterogeneity. In total, seven studies were identified consisting of 172 participants (experimental n = 84; control n = 88). The pooled results showed a moderate but significant effect of PRT on leg strength (SMD 1.42, 95% CI 0.464-2.376); however, no significant effects were observed for gait speed (SMD 0.418, 95% CI -0.219 to 1.055). No significant effects were observed for balance measures included in this review. In conclusion, our results showed no discernable effect of PRT on gait and balance measures, although this is likely due to the lack of studies available. It may be suggested that PRT be performed in conjunction with balance or task-specific functional training to elicit greater lower limb functional benefits in people with PD.

AB - The use of progressive resistance training (PRT) to improve gait and balance in people with Parkinson's disease (PD) is an emerging area of interest. However, the main effects of PRT on lower limb functions such as gait, balance, and leg strength in people with PD remain unclear. Therefore, the aim of the meta-analysis is to evaluate the evidence surrounding the use of PRT to improve gait and balance in people with PD. Five electronic databases, from inception to December 2014, were searched to identify the relevant studies. Data extraction was performed by two independent reviewers and methodological quality was assessed using the PEDro scale. Standardized mean differences (SMD) and 95% confidence intervals (CIs) of fixed and random effects models were used to calculate the effect sizes between experimental and control groups and I2 statistics were used to determine levels of heterogeneity. In total, seven studies were identified consisting of 172 participants (experimental n = 84; control n = 88). The pooled results showed a moderate but significant effect of PRT on leg strength (SMD 1.42, 95% CI 0.464-2.376); however, no significant effects were observed for gait speed (SMD 0.418, 95% CI -0.219 to 1.055). No significant effects were observed for balance measures included in this review. In conclusion, our results showed no discernable effect of PRT on gait and balance measures, although this is likely due to the lack of studies available. It may be suggested that PRT be performed in conjunction with balance or task-specific functional training to elicit greater lower limb functional benefits in people with PD.

KW - Balance

KW - Gait speed

KW - Leg strength

KW - Parkinson's disease

KW - Progressive resistance training

UR - http://www.scopus.com/inward/record.url?scp=84926318560&partnerID=8YFLogxK

U2 - 10.3389/fnagi.2015.00040

DO - 10.3389/fnagi.2015.00040

M3 - Review Article

VL - 7

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

IS - MAR

M1 - 40

ER -