Lower in vivo myo-inositol in the anterior cingulate cortex correlates with delayed melatonin rhythms in young persons with depression

Rébecca Robillard, Jim Lagopoulos, Daniel F. Hermens, Sharon Linda Naismith, Naomi L. Rogers, Django White, Joanne S. Carpenter, Manreena Kaur, Elizabeth M. Scott, Ian Bernard Hickie

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3 Citations (Scopus)


Myo-inositol, a second messenger glucose isomer and glial marker, is potentiated by melatonin. In addition to common abnormalities in melatonin regulation, depressive disorders have been associated with reduced myo-inositol in frontal structures. This study examined associations between myo-inositol in the anterior cingulate cortex and the timing of evening melatonin release. Forty young persons with unipolar depression were recruited from specialized mental health services (20.3 ± 3.8 years old). Healthy controls were recruited from the community (21.7 ± 2.6 years old). The timing of dim light melatonin onset (DLMO) was estimated using salivary melatonin sampling. Myo-inositol concentrations (MI/CrPCr ratio) in the anterior cingulate cortex were obtained using proton magnetic resonance spectroscopy. After controlling for age, sex, and CrPCr concentration the depression group had significantly lower MI/CrPCr ratios than healthy controls [F(4, 75) = 11.4, p = 0.001]. In the depression group, later DLMO correlated with lower MI/CrPCr ratio (r = -0.48, p = 0.014). These findings suggest that neurochemical changes in the frontal cortex are associated with circadian disruptions in young persons with depression.

Original languageEnglish
Article number336
JournalFrontiers in Neuroscience
Issue numberJUN
Publication statusPublished - 2017
Externally publishedYes


  • Circadian
  • Depression
  • Magnetic resonance spectroscopy
  • Melatonin
  • Myo-inositol

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