Low vitamin D is associated with hypertension in paediatric obesity

Kung-Ting Kao, Nobia Fatima Abidi, Sanjeeva Ranasinha, Justin Brown, Christine P Rodda, Zoe McCallum, Margaret Zacharin, Peter J Simm, Costan Magnussen, Matthew A Sabin

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aim The aim of this paper was to investigate the relationship between circulating 25-hydroxyVitamin D (25(OH)D) and cardio-metabolic risk factors in a large cohort of obese youth attending tertiary paediatric obesity services. Methods We conducted a retrospective cross-sectional study. Data were retrospectively collected from all new consultations of children and adolescents attending obesity outpatient clinics between 2008 and 2011 at the two major paediatric hospitals in Melbourne, Australia. Information collected included demographics, anthropometry, blood pressure, pubertal staging, body composition and fasting serum levels of 25(OH)D, glucose, insulin, cholesterol, triglyceride, high-density lipoprotein, liver function, calcium and phosphate. Results 25(OH)D data were available in 229 patients (age 3-18 years; 116 men; mean (standard deviation) body mass index (BMI) Z-score 2.5 (0.5)). One hundred four (45%) participants were 25(OH)D deficient (<50 nmol/L). Lower serum 25(OH)D levels were associated with higher BMI Z-score (P-trend = 0.001), total fat mass (P-trend = 0.009), systolic (P-trend = 0.03) and diastolic blood pressures(P-trend = 0.009). In multivariable-adjusted regression analysis, 25(OH)D was significantly lower in those with elevated blood pressure after adjustment for BMI(P-trend = 0.004) or total fat mass (P-trend = 0.01). Conclusion Overweight and obese youth attending specialist obesity services have a high prevalence of Vitamin D deficiency. In this population, lower levels of Vitamin D were seen in those with greater adiposity, and independent of this, in those who had higher blood pressure.

Original languageEnglish
Pages (from-to)1207 - 1213
Number of pages7
JournalJournal of Paediatrics and Child Health
Volume51
Issue number12
DOIs
Publication statusPublished - 1 Dec 2015

Keywords

  • children
  • hypertension
  • metabolic syndrome
  • obesity
  • Vitamin D

Cite this

Kao, K-T., Abidi, N. F., Ranasinha, S., Brown, J., Rodda, C. P., McCallum, Z., ... Sabin, M. A. (2015). Low vitamin D is associated with hypertension in paediatric obesity. Journal of Paediatrics and Child Health, 51(12), 1207 - 1213. https://doi.org/10.1111/jpc.12935
Kao, Kung-Ting ; Abidi, Nobia Fatima ; Ranasinha, Sanjeeva ; Brown, Justin ; Rodda, Christine P ; McCallum, Zoe ; Zacharin, Margaret ; Simm, Peter J ; Magnussen, Costan ; Sabin, Matthew A. / Low vitamin D is associated with hypertension in paediatric obesity. In: Journal of Paediatrics and Child Health. 2015 ; Vol. 51, No. 12. pp. 1207 - 1213.
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abstract = "Aim The aim of this paper was to investigate the relationship between circulating 25-hydroxyVitamin D (25(OH)D) and cardio-metabolic risk factors in a large cohort of obese youth attending tertiary paediatric obesity services. Methods We conducted a retrospective cross-sectional study. Data were retrospectively collected from all new consultations of children and adolescents attending obesity outpatient clinics between 2008 and 2011 at the two major paediatric hospitals in Melbourne, Australia. Information collected included demographics, anthropometry, blood pressure, pubertal staging, body composition and fasting serum levels of 25(OH)D, glucose, insulin, cholesterol, triglyceride, high-density lipoprotein, liver function, calcium and phosphate. Results 25(OH)D data were available in 229 patients (age 3-18 years; 116 men; mean (standard deviation) body mass index (BMI) Z-score 2.5 (0.5)). One hundred four (45{\%}) participants were 25(OH)D deficient (<50 nmol/L). Lower serum 25(OH)D levels were associated with higher BMI Z-score (P-trend = 0.001), total fat mass (P-trend = 0.009), systolic (P-trend = 0.03) and diastolic blood pressures(P-trend = 0.009). In multivariable-adjusted regression analysis, 25(OH)D was significantly lower in those with elevated blood pressure after adjustment for BMI(P-trend = 0.004) or total fat mass (P-trend = 0.01). Conclusion Overweight and obese youth attending specialist obesity services have a high prevalence of Vitamin D deficiency. In this population, lower levels of Vitamin D were seen in those with greater adiposity, and independent of this, in those who had higher blood pressure.",
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author = "Kung-Ting Kao and Abidi, {Nobia Fatima} and Sanjeeva Ranasinha and Justin Brown and Rodda, {Christine P} and Zoe McCallum and Margaret Zacharin and Simm, {Peter J} and Costan Magnussen and Sabin, {Matthew A}",
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Kao, K-T, Abidi, NF, Ranasinha, S, Brown, J, Rodda, CP, McCallum, Z, Zacharin, M, Simm, PJ, Magnussen, C & Sabin, MA 2015, 'Low vitamin D is associated with hypertension in paediatric obesity' Journal of Paediatrics and Child Health, vol. 51, no. 12, pp. 1207 - 1213. https://doi.org/10.1111/jpc.12935

Low vitamin D is associated with hypertension in paediatric obesity. / Kao, Kung-Ting; Abidi, Nobia Fatima; Ranasinha, Sanjeeva; Brown, Justin; Rodda, Christine P; McCallum, Zoe; Zacharin, Margaret; Simm, Peter J; Magnussen, Costan; Sabin, Matthew A.

In: Journal of Paediatrics and Child Health, Vol. 51, No. 12, 01.12.2015, p. 1207 - 1213.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Low vitamin D is associated with hypertension in paediatric obesity

AU - Kao, Kung-Ting

AU - Abidi, Nobia Fatima

AU - Ranasinha, Sanjeeva

AU - Brown, Justin

AU - Rodda, Christine P

AU - McCallum, Zoe

AU - Zacharin, Margaret

AU - Simm, Peter J

AU - Magnussen, Costan

AU - Sabin, Matthew A

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Aim The aim of this paper was to investigate the relationship between circulating 25-hydroxyVitamin D (25(OH)D) and cardio-metabolic risk factors in a large cohort of obese youth attending tertiary paediatric obesity services. Methods We conducted a retrospective cross-sectional study. Data were retrospectively collected from all new consultations of children and adolescents attending obesity outpatient clinics between 2008 and 2011 at the two major paediatric hospitals in Melbourne, Australia. Information collected included demographics, anthropometry, blood pressure, pubertal staging, body composition and fasting serum levels of 25(OH)D, glucose, insulin, cholesterol, triglyceride, high-density lipoprotein, liver function, calcium and phosphate. Results 25(OH)D data were available in 229 patients (age 3-18 years; 116 men; mean (standard deviation) body mass index (BMI) Z-score 2.5 (0.5)). One hundred four (45%) participants were 25(OH)D deficient (<50 nmol/L). Lower serum 25(OH)D levels were associated with higher BMI Z-score (P-trend = 0.001), total fat mass (P-trend = 0.009), systolic (P-trend = 0.03) and diastolic blood pressures(P-trend = 0.009). In multivariable-adjusted regression analysis, 25(OH)D was significantly lower in those with elevated blood pressure after adjustment for BMI(P-trend = 0.004) or total fat mass (P-trend = 0.01). Conclusion Overweight and obese youth attending specialist obesity services have a high prevalence of Vitamin D deficiency. In this population, lower levels of Vitamin D were seen in those with greater adiposity, and independent of this, in those who had higher blood pressure.

AB - Aim The aim of this paper was to investigate the relationship between circulating 25-hydroxyVitamin D (25(OH)D) and cardio-metabolic risk factors in a large cohort of obese youth attending tertiary paediatric obesity services. Methods We conducted a retrospective cross-sectional study. Data were retrospectively collected from all new consultations of children and adolescents attending obesity outpatient clinics between 2008 and 2011 at the two major paediatric hospitals in Melbourne, Australia. Information collected included demographics, anthropometry, blood pressure, pubertal staging, body composition and fasting serum levels of 25(OH)D, glucose, insulin, cholesterol, triglyceride, high-density lipoprotein, liver function, calcium and phosphate. Results 25(OH)D data were available in 229 patients (age 3-18 years; 116 men; mean (standard deviation) body mass index (BMI) Z-score 2.5 (0.5)). One hundred four (45%) participants were 25(OH)D deficient (<50 nmol/L). Lower serum 25(OH)D levels were associated with higher BMI Z-score (P-trend = 0.001), total fat mass (P-trend = 0.009), systolic (P-trend = 0.03) and diastolic blood pressures(P-trend = 0.009). In multivariable-adjusted regression analysis, 25(OH)D was significantly lower in those with elevated blood pressure after adjustment for BMI(P-trend = 0.004) or total fat mass (P-trend = 0.01). Conclusion Overweight and obese youth attending specialist obesity services have a high prevalence of Vitamin D deficiency. In this population, lower levels of Vitamin D were seen in those with greater adiposity, and independent of this, in those who had higher blood pressure.

KW - children

KW - hypertension

KW - metabolic syndrome

KW - obesity

KW - Vitamin D

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DO - 10.1111/jpc.12935

M3 - Article

VL - 51

SP - 1207

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