Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth

Sonia Soo Yee Teoh, Yao Wang, Ying Li, Shalem Yiner Lee Leemaqz, Gus A. Dekker, Claire T. Roberts, Guiying Nie

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: The aim of this study was to investigate the potential utility of serum HtrA1 and HtrA3, serine proteases that are highly expressed in the developing placenta, at 15 and 20 weeks of gestation for predicting later development of adverse pregnancy outcomes of preeclampsia (PE), gestational hypertension (GHT), preterm birth (PTB), and small for gestational age (SGA) birth. Methods: This is a nested case control study of 665 samples (330 controls, 335 cases) from the Adelaide SCOPE cohort. The cases included were 92 PE, 71 GHT, 56 PTB, and 116 SGA. Samples were assessed by ELISA and data adjusted for maternal age, BMI, socioeconomic index, hCG, and smoking status. Multivariate logistic regression was performed with other biochemical and biophysical parameters available for these samples. Results: HtrA1 did not differ between the controls and cases. In contrast, HtrA3 was significantly lower at 15 weeks in pregnancies that later developed late-onset PE (LPE) or resulted in SGA birth, with an area under the ROC curve (AUC) of 0.716 and 0.790, respectively. The combination of HtrA3 with PAPP-A, uterine, and umbilical Doppler improved the AUC to 0.755 for LPE and 0.844 for SGA. Conclusion: HtrA3 at 15 weeks is associated with, and may be useful for, the early detection of LPE development and SGA birth.

Original languageEnglish
Number of pages10
JournalFetal Diagnosis and Therapy
DOIs
Publication statusAccepted/In press - 3 Apr 2019

Keywords

  • Biomarkers
  • HtrA1
  • HtrA3
  • Late-onset preeclampsia
  • Preeclampsia
  • Small for gestational age

Cite this

Teoh, Sonia Soo Yee ; Wang, Yao ; Li, Ying ; Leemaqz, Shalem Yiner Lee ; Dekker, Gus A. ; Roberts, Claire T. ; Nie, Guiying. / Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth. In: Fetal Diagnosis and Therapy. 2019.
@article{1c01da44448648979235db3ae48d20b8,
title = "Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth",
abstract = "Objective: The aim of this study was to investigate the potential utility of serum HtrA1 and HtrA3, serine proteases that are highly expressed in the developing placenta, at 15 and 20 weeks of gestation for predicting later development of adverse pregnancy outcomes of preeclampsia (PE), gestational hypertension (GHT), preterm birth (PTB), and small for gestational age (SGA) birth. Methods: This is a nested case control study of 665 samples (330 controls, 335 cases) from the Adelaide SCOPE cohort. The cases included were 92 PE, 71 GHT, 56 PTB, and 116 SGA. Samples were assessed by ELISA and data adjusted for maternal age, BMI, socioeconomic index, hCG, and smoking status. Multivariate logistic regression was performed with other biochemical and biophysical parameters available for these samples. Results: HtrA1 did not differ between the controls and cases. In contrast, HtrA3 was significantly lower at 15 weeks in pregnancies that later developed late-onset PE (LPE) or resulted in SGA birth, with an area under the ROC curve (AUC) of 0.716 and 0.790, respectively. The combination of HtrA3 with PAPP-A, uterine, and umbilical Doppler improved the AUC to 0.755 for LPE and 0.844 for SGA. Conclusion: HtrA3 at 15 weeks is associated with, and may be useful for, the early detection of LPE development and SGA birth.",
keywords = "Biomarkers, HtrA1, HtrA3, Late-onset preeclampsia, Preeclampsia, Small for gestational age",
author = "Teoh, {Sonia Soo Yee} and Yao Wang and Ying Li and Leemaqz, {Shalem Yiner Lee} and Dekker, {Gus A.} and Roberts, {Claire T.} and Guiying Nie",
year = "2019",
month = "4",
day = "3",
doi = "10.1159/000497144",
language = "English",
journal = "Fetal Diagnosis and Therapy",
issn = "1015-3837",
publisher = "Karger",

}

Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth. / Teoh, Sonia Soo Yee; Wang, Yao; Li, Ying; Leemaqz, Shalem Yiner Lee; Dekker, Gus A.; Roberts, Claire T.; Nie, Guiying.

In: Fetal Diagnosis and Therapy, 03.04.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth

AU - Teoh, Sonia Soo Yee

AU - Wang, Yao

AU - Li, Ying

AU - Leemaqz, Shalem Yiner Lee

AU - Dekker, Gus A.

AU - Roberts, Claire T.

AU - Nie, Guiying

PY - 2019/4/3

Y1 - 2019/4/3

N2 - Objective: The aim of this study was to investigate the potential utility of serum HtrA1 and HtrA3, serine proteases that are highly expressed in the developing placenta, at 15 and 20 weeks of gestation for predicting later development of adverse pregnancy outcomes of preeclampsia (PE), gestational hypertension (GHT), preterm birth (PTB), and small for gestational age (SGA) birth. Methods: This is a nested case control study of 665 samples (330 controls, 335 cases) from the Adelaide SCOPE cohort. The cases included were 92 PE, 71 GHT, 56 PTB, and 116 SGA. Samples were assessed by ELISA and data adjusted for maternal age, BMI, socioeconomic index, hCG, and smoking status. Multivariate logistic regression was performed with other biochemical and biophysical parameters available for these samples. Results: HtrA1 did not differ between the controls and cases. In contrast, HtrA3 was significantly lower at 15 weeks in pregnancies that later developed late-onset PE (LPE) or resulted in SGA birth, with an area under the ROC curve (AUC) of 0.716 and 0.790, respectively. The combination of HtrA3 with PAPP-A, uterine, and umbilical Doppler improved the AUC to 0.755 for LPE and 0.844 for SGA. Conclusion: HtrA3 at 15 weeks is associated with, and may be useful for, the early detection of LPE development and SGA birth.

AB - Objective: The aim of this study was to investigate the potential utility of serum HtrA1 and HtrA3, serine proteases that are highly expressed in the developing placenta, at 15 and 20 weeks of gestation for predicting later development of adverse pregnancy outcomes of preeclampsia (PE), gestational hypertension (GHT), preterm birth (PTB), and small for gestational age (SGA) birth. Methods: This is a nested case control study of 665 samples (330 controls, 335 cases) from the Adelaide SCOPE cohort. The cases included were 92 PE, 71 GHT, 56 PTB, and 116 SGA. Samples were assessed by ELISA and data adjusted for maternal age, BMI, socioeconomic index, hCG, and smoking status. Multivariate logistic regression was performed with other biochemical and biophysical parameters available for these samples. Results: HtrA1 did not differ between the controls and cases. In contrast, HtrA3 was significantly lower at 15 weeks in pregnancies that later developed late-onset PE (LPE) or resulted in SGA birth, with an area under the ROC curve (AUC) of 0.716 and 0.790, respectively. The combination of HtrA3 with PAPP-A, uterine, and umbilical Doppler improved the AUC to 0.755 for LPE and 0.844 for SGA. Conclusion: HtrA3 at 15 weeks is associated with, and may be useful for, the early detection of LPE development and SGA birth.

KW - Biomarkers

KW - HtrA1

KW - HtrA3

KW - Late-onset preeclampsia

KW - Preeclampsia

KW - Small for gestational age

UR - http://www.scopus.com/inward/record.url?scp=85064993334&partnerID=8YFLogxK

U2 - 10.1159/000497144

DO - 10.1159/000497144

M3 - Article

JO - Fetal Diagnosis and Therapy

JF - Fetal Diagnosis and Therapy

SN - 1015-3837

ER -