Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

Jing He, Xia Zhang, Yunbo Wei, Xiaolin Sun, Yaping Chen, Jun Deng, Yuebo Jin, Yuzhou Gan, Xin Hu, Rulin Jia, Chuanhui Xu, Zhaohua Hou, Yew Ann Leong, Lei Zhu, Jinhong Feng, Yuan An, Yuan Jia, Chun Li, Xu Liu, Hua Ye & 12 others Limin Ren, Ru Li, Haihong Yao, Yuhui Li, Shi Chen, Xuewu Zhang, Yin Su, Jianping Guo, Nan Shen, Eric F Morand, Di Yu, Zhanguo Li

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease characterized by altered balance of activity between effector and regulatory CD4+ T cells. The homeostasis of CD4+ T cell subsets is regulated by interleukin (IL)-2, and reduced production of IL-2 by T cells is observed in individuals with SLE. Here we report that treatment with low-dose recombinant human IL-2 selectively modulated the abundance of regulatory T (Treg) cells, follicular helper T (TFH) cells and IL-17-producing helper T (TH17) cells, but not TH1 or TH2 cells, accompanied by marked reductions of disease activity in patients with SLE.

Original languageEnglish
Pages (from-to)991-993
Number of pages3
JournalNature Medicine
Volume22
Issue number9
DOIs
Publication statusPublished - Sep 2016

Keywords

  • autoimmunity
  • regulatory T cells
  • systemic lupus erythematosus

Cite this

He, Jing ; Zhang, Xia ; Wei, Yunbo ; Sun, Xiaolin ; Chen, Yaping ; Deng, Jun ; Jin, Yuebo ; Gan, Yuzhou ; Hu, Xin ; Jia, Rulin ; Xu, Chuanhui ; Hou, Zhaohua ; Leong, Yew Ann ; Zhu, Lei ; Feng, Jinhong ; An, Yuan ; Jia, Yuan ; Li, Chun ; Liu, Xu ; Ye, Hua ; Ren, Limin ; Li, Ru ; Yao, Haihong ; Li, Yuhui ; Chen, Shi ; Zhang, Xuewu ; Su, Yin ; Guo, Jianping ; Shen, Nan ; Morand, Eric F ; Yu, Di ; Li, Zhanguo. / Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus. In: Nature Medicine. 2016 ; Vol. 22, No. 9. pp. 991-993.
@article{13306bba86e04b6a8f684f0aaf9fdcfc,
title = "Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus",
abstract = "Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease characterized by altered balance of activity between effector and regulatory CD4+ T cells. The homeostasis of CD4+ T cell subsets is regulated by interleukin (IL)-2, and reduced production of IL-2 by T cells is observed in individuals with SLE. Here we report that treatment with low-dose recombinant human IL-2 selectively modulated the abundance of regulatory T (Treg) cells, follicular helper T (TFH) cells and IL-17-producing helper T (TH17) cells, but not TH1 or TH2 cells, accompanied by marked reductions of disease activity in patients with SLE.",
keywords = "autoimmunity, regulatory T cells, systemic lupus erythematosus",
author = "Jing He and Xia Zhang and Yunbo Wei and Xiaolin Sun and Yaping Chen and Jun Deng and Yuebo Jin and Yuzhou Gan and Xin Hu and Rulin Jia and Chuanhui Xu and Zhaohua Hou and Leong, {Yew Ann} and Lei Zhu and Jinhong Feng and Yuan An and Yuan Jia and Chun Li and Xu Liu and Hua Ye and Limin Ren and Ru Li and Haihong Yao and Yuhui Li and Shi Chen and Xuewu Zhang and Yin Su and Jianping Guo and Nan Shen and Morand, {Eric F} and Di Yu and Zhanguo Li",
year = "2016",
month = "9",
doi = "10.1038/nm.4148",
language = "English",
volume = "22",
pages = "991--993",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "9",

}

He, J, Zhang, X, Wei, Y, Sun, X, Chen, Y, Deng, J, Jin, Y, Gan, Y, Hu, X, Jia, R, Xu, C, Hou, Z, Leong, YA, Zhu, L, Feng, J, An, Y, Jia, Y, Li, C, Liu, X, Ye, H, Ren, L, Li, R, Yao, H, Li, Y, Chen, S, Zhang, X, Su, Y, Guo, J, Shen, N, Morand, EF, Yu, D & Li, Z 2016, 'Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus' Nature Medicine, vol. 22, no. 9, pp. 991-993. https://doi.org/10.1038/nm.4148

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus. / He, Jing; Zhang, Xia; Wei, Yunbo; Sun, Xiaolin; Chen, Yaping; Deng, Jun; Jin, Yuebo; Gan, Yuzhou; Hu, Xin; Jia, Rulin; Xu, Chuanhui; Hou, Zhaohua; Leong, Yew Ann; Zhu, Lei; Feng, Jinhong; An, Yuan; Jia, Yuan; Li, Chun; Liu, Xu; Ye, Hua; Ren, Limin; Li, Ru; Yao, Haihong; Li, Yuhui; Chen, Shi; Zhang, Xuewu; Su, Yin; Guo, Jianping; Shen, Nan; Morand, Eric F; Yu, Di; Li, Zhanguo.

In: Nature Medicine, Vol. 22, No. 9, 09.2016, p. 991-993.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

AU - He, Jing

AU - Zhang, Xia

AU - Wei, Yunbo

AU - Sun, Xiaolin

AU - Chen, Yaping

AU - Deng, Jun

AU - Jin, Yuebo

AU - Gan, Yuzhou

AU - Hu, Xin

AU - Jia, Rulin

AU - Xu, Chuanhui

AU - Hou, Zhaohua

AU - Leong, Yew Ann

AU - Zhu, Lei

AU - Feng, Jinhong

AU - An, Yuan

AU - Jia, Yuan

AU - Li, Chun

AU - Liu, Xu

AU - Ye, Hua

AU - Ren, Limin

AU - Li, Ru

AU - Yao, Haihong

AU - Li, Yuhui

AU - Chen, Shi

AU - Zhang, Xuewu

AU - Su, Yin

AU - Guo, Jianping

AU - Shen, Nan

AU - Morand, Eric F

AU - Yu, Di

AU - Li, Zhanguo

PY - 2016/9

Y1 - 2016/9

N2 - Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease characterized by altered balance of activity between effector and regulatory CD4+ T cells. The homeostasis of CD4+ T cell subsets is regulated by interleukin (IL)-2, and reduced production of IL-2 by T cells is observed in individuals with SLE. Here we report that treatment with low-dose recombinant human IL-2 selectively modulated the abundance of regulatory T (Treg) cells, follicular helper T (TFH) cells and IL-17-producing helper T (TH17) cells, but not TH1 or TH2 cells, accompanied by marked reductions of disease activity in patients with SLE.

AB - Systemic lupus erythematosus (SLE) is a potentially life-threatening autoimmune disease characterized by altered balance of activity between effector and regulatory CD4+ T cells. The homeostasis of CD4+ T cell subsets is regulated by interleukin (IL)-2, and reduced production of IL-2 by T cells is observed in individuals with SLE. Here we report that treatment with low-dose recombinant human IL-2 selectively modulated the abundance of regulatory T (Treg) cells, follicular helper T (TFH) cells and IL-17-producing helper T (TH17) cells, but not TH1 or TH2 cells, accompanied by marked reductions of disease activity in patients with SLE.

KW - autoimmunity

KW - regulatory T cells

KW - systemic lupus erythematosus

UR - http://www.scopus.com/inward/record.url?scp=84981163508&partnerID=8YFLogxK

U2 - 10.1038/nm.4148

DO - 10.1038/nm.4148

M3 - Article

VL - 22

SP - 991

EP - 993

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 9

ER -