Low-dose antacids and nonsteroidal anti-inflammatory drug-induced gastropathy in humans

William Sievert, Anthony I. Stern, John R. Lambert, Tracy Peacock

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Gastroduodenal injury induced by nonsteroidal anti-inflammatory drugs (NSAIDs) is common. As yet, the ideal means to prevent NSAID-related mucosal injury remains controversial. Antacids are effective agents in treating gastric and duodenal ulcers unrelated to NSAIDs. The aim of this study was to assess the ability of a low-dose antacid to prevent NSAID injury in humans. Fifty healthy human volunteers were studied using a randomized, double-blind, placebo controlled, crossover design. After initial endoscopy, subjects were randomized to either Maalox TC (1 tablet q.i.d., acid neutralizing capacity of 104 mEq/day) or identical placebo while receiving 500 mg of naproxen b.i.d. for 21 days. After this period, a second endoscopy was performed to count antral and duodenal erosions and to evaluate symptoms and compliance with study medications. A 21-day washout period ensued, followed by a third endoscopy to insure a return to endoscopically normal mucosa. Subjects then crossed over into the alternate treatment arm for a further 21 days, followed by a fourth endoscopy to assess erosions. Forty subjects completed the study. Subjects receiving Maalox TC developed a significantly greater number of gastric erosions than did those on placebo. While this result was unforeseen, it is supported by statistical analysis and may have clinical relevance in regard to short-term NSAID therapy.

Original languageEnglish
Pages (from-to)S145-S148
Number of pages4
JournalJournal of Clinical Gastroenterology
Volume13
DOIs
Publication statusPublished - 1 Jan 1991

Keywords

  • Duodenal ulcer
  • Gastric ulcer
  • Humans
  • Low-dose antacids
  • Nonsteroidal anti-inflammatory drugs

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