TY - JOUR
T1 - Low dose angiotensin II infusions into the renal artery induce chronic hypertension in conscious dogs
AU - Fitzgerald, Sharyn M.
AU - Stevenson, Kathleen M.
AU - Evans, Roger G.
AU - Anderson, Warwick P.
PY - 1997/1
Y1 - 1997/1
N2 - Angiotensin II was infused at 0.5 ng/kg/min either directly into the left renal artery (n = 5) or intravenously (n = 4) for 28 days in conscious dogs. Renal artery infusion of angiotensin II had no significant effect on mean arterial pressure after 1 and 24 h, but pressure had increased by 12 ± 2, 12 ± 4, 8 ± 3 and 13 ± 3 mmHg on days 7, 14, 21 and 28, respectively, during infusion. Renal blood flow decreased significantly at 24 hours (p = 0.02) but was not significantly reduced subsequently. Over days 7- 28, central venous pressure and haematocrit rose significantly but body weight did not change significantly. During intravenous infusion of angiotensin II, arterial pressure increased (5 ± 4, 7 ± 5 and 5 ± 3 mmHg on days 7, 14 and 21, respectively), body weight rose and haematocrit fell significantly, but central venous pressure did not change. Thus, angiotensin II infused into the renal artery, at a dose which had no initial pressor effect, produced chronic, stable hypertension, with equivocal evidence of renal fluid retention. We conclude that elevated levels of angiotensin II in the kidney alone can cause chronic hypertension.
AB - Angiotensin II was infused at 0.5 ng/kg/min either directly into the left renal artery (n = 5) or intravenously (n = 4) for 28 days in conscious dogs. Renal artery infusion of angiotensin II had no significant effect on mean arterial pressure after 1 and 24 h, but pressure had increased by 12 ± 2, 12 ± 4, 8 ± 3 and 13 ± 3 mmHg on days 7, 14, 21 and 28, respectively, during infusion. Renal blood flow decreased significantly at 24 hours (p = 0.02) but was not significantly reduced subsequently. Over days 7- 28, central venous pressure and haematocrit rose significantly but body weight did not change significantly. During intravenous infusion of angiotensin II, arterial pressure increased (5 ± 4, 7 ± 5 and 5 ± 3 mmHg on days 7, 14 and 21, respectively), body weight rose and haematocrit fell significantly, but central venous pressure did not change. Thus, angiotensin II infused into the renal artery, at a dose which had no initial pressor effect, produced chronic, stable hypertension, with equivocal evidence of renal fluid retention. We conclude that elevated levels of angiotensin II in the kidney alone can cause chronic hypertension.
KW - angiotensin II
KW - dog
KW - hypertension
KW - plasma renin activity
KW - renal blood flow
UR - http://www.scopus.com/inward/record.url?scp=0031025593&partnerID=8YFLogxK
M3 - Article
C2 - 9116928
AN - SCOPUS:0031025593
SN - 0803-7051
VL - 6
SP - 52
EP - 61
JO - Blood Pressure
JF - Blood Pressure
IS - 1
ER -