Research output per year
Research output per year
Jordi Mayneris-Perxachs, Aya Mousa, Negar Naderpoor, José Manuel Fernández-Real, Barbora de Courten
Research output: Contribution to journal › Article › Research › peer-review
Scope: Reduced amylase 1 (AMY1) copy numbers are associated with obesity, insulin resistance, and inflammation. Although mechanisms linking AMY1 copy number with metabolic disorders are poorly understood, recent findings suggest that lipids play a key role. Methods and results: Plasma lipidomic signatures associated with AMY1 copy number are explored in 57 non-diabetic overweight/obese subjects aged 18–60. Serum amylase and inflammatory cytokines levels are also measured. AMY1 copy number is strongly associated with the serum amylase concentration. Participants are divided into low-(≤4) and high-(>4) AMY1 carriers based on the median. Low-AMY1 carriers have higher BMI and fat mass. They also have higher levels of dihexosylceramides (R = −0.27, p = 0.044), cholesterol esters (CE) (R = −0.32, p = 0.020), alkylphosphatidylcholines [PC(O)] (R = −0.33, p = 0.014), and sphingomyelins (SM) (R = −0.38, p = 0.005). From 459 lipid species, 28 differ between low- and high-AMY1 carriers. These include CE species with long-chain PUFA; PC(O) and PC plasmalogens containing arachidonic acid; and PC, mono-, di-, and tri-hexosylceramides, and SM containing saturated fatty acids (mainly C16:0 and C20:0). This lipidomic signature is strongly associated with inflammatory cytokines, which are also negatively associated with the AMY1 copy number. Conclusion: A lipidomics signature associated with low AMY1 copy numbers is revealed, which is linked to obesity and chronic low-grade inflammation.
Original language | English |
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Article number | 1901151 |
Number of pages | 10 |
Journal | Molecular Nutrition & Food Research |
Volume | 64 |
Issue number | 11 |
DOIs | |
Publication status | Published - Jun 2020 |
Research output: Contribution to journal › Comment / Debate › Other › peer-review
de Courten, B. (Primary Chief Investigator (PCI))
National Heart Foundation of Australia
1/01/16 → 31/12/19
Project: Research
de Courten, B. (Primary Chief Investigator (PCI)), De Courten, M. (Chief Investigator (CI)), Scragg, R. (Chief Investigator (CI)) & Walker, K. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/14 → 31/12/17
Project: Research