Loss of response to long-term infliximab therapy in children with Crohn's disease

Oliver Gouldthorpe; Anthony Catto-Smith; George Alex; Dianne M Simpson

doi:10.3390/ph6101322

Loss of response to long-term infliximab therapy in children with Crohn's disease

Oliver Gouldthorpe
, Anthony Catto-Smith
, George Alex
, Dianne M Simpson

Paediatrics Monash Health

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

Secondary loss of response (LoR) often precludes further use of infliximab in children with Crohn s disease. Immunomodulators may reduce the incidence of LoR but their combination with infliximab presents safety concerns. We aimed to determine the long-term durability of infliximab response in paediatric Crohn s, effect of immunomodulators on LoR, and secondarily the effect of infliximab on growth.

Original language	English
Pages (from-to)	1322-1334
Number of pages	13
Journal	Pharmaceuticals
Volume	6
DOIs	https://doi.org/10.3390/ph6101322
Publication status	Published - 2013

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10.3390/ph6101322

Cite this

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title = "Loss of response to long-term infliximab therapy in children with Crohn's disease",

abstract = "Secondary loss of response (LoR) often precludes further use of infliximab in children with Crohn s disease. Immunomodulators may reduce the incidence of LoR but their combination with infliximab presents safety concerns. We aimed to determine the long-term durability of infliximab response in paediatric Crohn s, effect of immunomodulators on LoR, and secondarily the effect of infliximab on growth.",

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AU - Catto-Smith, Anthony

AU - Alex, George

AU - Simpson, Dianne M

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AB - Secondary loss of response (LoR) often precludes further use of infliximab in children with Crohn s disease. Immunomodulators may reduce the incidence of LoR but their combination with infliximab presents safety concerns. We aimed to determine the long-term durability of infliximab response in paediatric Crohn s, effect of immunomodulators on LoR, and secondarily the effect of infliximab on growth.

U2 - 10.3390/ph6101322

DO - 10.3390/ph6101322

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JO - Pharmaceuticals

JF - Pharmaceuticals

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