Loss of response to long-term infliximab therapy in children with Crohn's disease

Oliver Gouldthorpe, Anthony Catto-Smith, George Alex, Dianne M Simpson

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)


Secondary loss of response (LoR) often precludes further use of infliximab in children with Crohn s disease. Immunomodulators may reduce the incidence of LoR but their combination with infliximab presents safety concerns. We aimed to determine the long-term durability of infliximab response in paediatric Crohn s, effect of immunomodulators on LoR, and secondarily the effect of infliximab on growth.
Original languageEnglish
Pages (from-to)1322-1334
Number of pages13
Publication statusPublished - 2013

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