Loss of response to long-term infliximab therapy in children with Crohn's disease

Oliver Gouldthorpe, Anthony Catto-Smith, George Alex, Dianne M Simpson

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Secondary loss of response (LoR) often precludes further use of infliximab in children with Crohn s disease. Immunomodulators may reduce the incidence of LoR but their combination with infliximab presents safety concerns. We aimed to determine the long-term durability of infliximab response in paediatric Crohn s, effect of immunomodulators on LoR, and secondarily the effect of infliximab on growth.
Original languageEnglish
Pages (from-to)1322 - 1334
Number of pages13
JournalPharmaceuticals
Volume6
DOIs
Publication statusPublished - 2013

Cite this

Gouldthorpe, O., Catto-Smith, A., Alex, G., & Simpson, D. M. (2013). Loss of response to long-term infliximab therapy in children with Crohn's disease. Pharmaceuticals, 6, 1322 - 1334. https://doi.org/10.3390/ph6101322
Gouldthorpe, Oliver ; Catto-Smith, Anthony ; Alex, George ; Simpson, Dianne M. / Loss of response to long-term infliximab therapy in children with Crohn's disease. In: Pharmaceuticals. 2013 ; Vol. 6. pp. 1322 - 1334.
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Gouldthorpe, O, Catto-Smith, A, Alex, G & Simpson, DM 2013, 'Loss of response to long-term infliximab therapy in children with Crohn's disease', Pharmaceuticals, vol. 6, pp. 1322 - 1334. https://doi.org/10.3390/ph6101322

Loss of response to long-term infliximab therapy in children with Crohn's disease. / Gouldthorpe, Oliver; Catto-Smith, Anthony; Alex, George; Simpson, Dianne M.

In: Pharmaceuticals, Vol. 6, 2013, p. 1322 - 1334.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Loss of response to long-term infliximab therapy in children with Crohn's disease

AU - Gouldthorpe, Oliver

AU - Catto-Smith, Anthony

AU - Alex, George

AU - Simpson, Dianne M

PY - 2013

Y1 - 2013

N2 - Secondary loss of response (LoR) often precludes further use of infliximab in children with Crohn s disease. Immunomodulators may reduce the incidence of LoR but their combination with infliximab presents safety concerns. We aimed to determine the long-term durability of infliximab response in paediatric Crohn s, effect of immunomodulators on LoR, and secondarily the effect of infliximab on growth.

AB - Secondary loss of response (LoR) often precludes further use of infliximab in children with Crohn s disease. Immunomodulators may reduce the incidence of LoR but their combination with infliximab presents safety concerns. We aimed to determine the long-term durability of infliximab response in paediatric Crohn s, effect of immunomodulators on LoR, and secondarily the effect of infliximab on growth.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817600/pdf/pharmaceuticals-06-01322.pdf

U2 - 10.3390/ph6101322

DO - 10.3390/ph6101322

M3 - Article

VL - 6

SP - 1322

EP - 1334

JO - Pharmaceuticals

JF - Pharmaceuticals

SN - 1424-8247

ER -