Projects per year
Abstract
Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, thereby contributing directly to the regulation of homeostasis. We have shown that from early embryonic development Bcl-G, a Bcl-2 protein family member with unknown function, was highly expressed in gastrointestinal epithelial cells. While Bcl-G was dispensable for normal growth and development in mice, the loss of Bcl-G resulted in accelerated progression of colitis-associated cancer. A label-free quantitative proteomics approach revealed that Bcl-G may contribute to the stability of a mucin network, which when disrupted, is linked to colon tumorigenesis. Consistent with this, we observed a significant reduction in Bcl-G expression in human colorectal tumors. Our study identifies an unappreciated role for Bcl-G in colon cancer.
Original language | English |
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Pages (from-to) | 742-757 |
Number of pages | 16 |
Journal | Cell Death and Differentiation |
Volume | 27 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2020 |
Keywords
- cancer models
- tumour-suppressor proteins
Projects
- 1 Finished
-
A Systems Approach to the Adaptive Immune Response
Hodgkin, P. D., Corcoran, L. M., Tarlinton, D., Belz, G. T. & Nutt, S. L.
1/01/14 → 31/12/18
Project: Research