Structural brain changes with life trauma and re-experiencing symptoms are 5-HTTLPR genotype dependent

Translated title of the contribution: Los cambios estructurales cerebrales con trauma en la vida y síntomas de reexperimentación son dependientes del genotipo 5-HTTLPR

Marie Laure Ancelin, Isabelle Carriere, Sylvaine Artero, Jerome J. Maller, Chantal Meslin, Anne Marie Dupuy, Karen Ritchie, Joanne Ryan, Isabelle Chaudieu

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Findings on structural brain alterations following trauma are inconsistent due probably to heterogeneity in imaging studies and population, clinical presentations, genetic vulnerability, and selection of controls. This study examines whether trauma and re-experiencing symptoms are associated with specific alterations in grey matter volumes and if this varies according to 5-HTTLPR genotype. Methods: Structural MRI was used to acquire anatomical scans from 377 community-dwelling older adults. Quantitative regional estimates of 22 subregional volumes were derived using FreeSurfer software. Lifetime trauma was assessed using the validated Watson’s PTSD inventory, which evaluates the most severe trauma experienced according to DSM criteria. Analyses adjusted for age, sex, total brain volume, head injury, and comorbidities. Results: Of the 212 participants reporting lifetime trauma, 35.4% reported re-experiencing symptoms and for 1.9%, this was severe enough to meet criteria for full threshold PTSD. In participants with the SS 5-HTTLPR genotype only, re-experiencing symptoms were associated with smaller volumes in middle and superior temporal, frontal (lateral orbital, rostral and caudal middle) and parietal (precuneus, inferior and superior) regions. The trauma-exposed participants without re-experiencing symptoms were not significantly different from the non-trauma-exposed participants except for smaller precuneus and superior parietal region in traumatized participants and a larger amygdala in traumatized women specifically. Conclusions: In the non-clinical sample, lifetime trauma and re-experiencing symptoms were associated with smaller volume in prefrontal, temporal and parietal cortex subregions, and this varied according to serotonergic genetic vulnerability, 5-HTTLPR SS individuals being most susceptible.

Translated title of the contributionLos cambios estructurales cerebrales con trauma en la vida y síntomas de reexperimentación son dependientes del genotipo 5-HTTLPR
Original languageSpanish
Article number1733247
Number of pages11
JournalEuropean Journal of Psychotraumatology
Volume11
Issue number1
DOIs
Publication statusPublished - 31 Dec 2020

Keywords

  • Ageing
  • cohort
  • grey matter volume
  • lifetime trauma
  • MRI
  • re-experiencing
  • serotonin transporter-linked promoter region
  • stress

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