Looped flow RAFT polymerization for multiblock copolymer synthesis

Agnès Kuroki; Ivan Martinez-Botella; Christian H. Hornung; Liam Martin; Elizabeth G.L. Williams; Katherine E S Locock; Matthias Hartlieb; Sébastien Perrier

doi:10.1039/c7py00630f

Looped flow RAFT polymerization for multiblock copolymer synthesis

Agnès Kuroki
, Ivan Martinez-Botella
, Christian H. Hornung
, Liam Martin
, Elizabeth G.L. Williams
, Katherine E S Locock
, Matthias Hartlieb
, Sébastien Perrier

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

50 Citations (Scopus)

Abstract

A looped flow process was designed for the synthesis of well-defined multiblock copolymers using reversible addition-fragmentation chain transfer (RAFT) polymerization. The reaction conditions were optimized to reach high conversions whilst maintaining a high end-group fidelity. The loop set-up proved to be a flexible, robust and time-efficient process for scaling-up multiblock copolymers.

Original language	English
Pages (from-to)	3249-3254
Number of pages	6
Journal	Polymer Chemistry
Volume	8
Issue number	21
DOIs	https://doi.org/10.1039/c7py00630f
Publication status	Published - 2017

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10.1039/c7py00630f

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AU - Kuroki, Agnès

AU - Martinez-Botella, Ivan

AU - Hornung, Christian H.

AU - Martin, Liam

AU - Williams, Elizabeth G.L.

AU - Locock, Katherine E S

AU - Hartlieb, Matthias

AU - Perrier, Sébastien

PY - 2017

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AB - A looped flow process was designed for the synthesis of well-defined multiblock copolymers using reversible addition-fragmentation chain transfer (RAFT) polymerization. The reaction conditions were optimized to reach high conversions whilst maintaining a high end-group fidelity. The loop set-up proved to be a flexible, robust and time-efficient process for scaling-up multiblock copolymers.

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U2 - 10.1039/c7py00630f

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SP - 3249

EP - 3254

JO - Polymer Chemistry

JF - Polymer Chemistry

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Looped flow RAFT polymerization for multiblock copolymer synthesis

Abstract

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