Longitudinal associations between microstructural changes and microperimetry in the early stages of age-related macular degeneration

Zhichao Wu, David Cunefare, Elizabeth Chiu, Chi D. Luu, Lauren N. Ayton, Cynthia A. Toth, Sina Farsiu, Robyn H. Guymer

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)


PURPOSE. To determine whether longitudinal changes in mesopic visual function on microperimetry occurred independent of its associations with microstructural parameters on spectral-domain optical coherence tomography (SD-OCT) in the early stages of AMD. METHODS. Forty-one AMD eyes underwent microperimetry testing and SD-OCT scans over a 12-month period at 6-month intervals. Microstructural parameters analyzed include the retinal pigment epithelium-drusen complex (RPEDC) layer thickness, number of hyperreflective foci (HF) and their inner retinal migration (represented by a weighted axial distribution score; AxD), and the number of atrophic areas. RESULTS. Microperimetric sensitivity was 0.29 dB (95% confidence interval [CI] =-0.38 to-0.20 dB, P < 0.001) and-0.13 dB (95% CI =-0.22 to-0.03 dB, P =-0.008) lower in each sector for every 10-μm higher RPEDC layer thickness and 1-HF present, but was not associated with the AxD score or the number of atrophic areas present (P ≤ 0.464). However, each 10μm greater RPEDC layer thickness and 1-HF present was not independently associated with a further decline in sensitivity (-0.08 dB/year, 95% CI =-0.24 to 0.07 dB/year, P = 0.288 and 0.09 dB/year, 95% CI =-0.06 to 0.24 dB/year, P = 0.242, respectively) over time when accounting for the association between RPEDC layer thickness and number of HF with microperimetric sensitivity. CONCLUSIONS. Longitudinal changes in mesopic visual function measured on microperimetry paralleled changes in the microstructural changes over a 12-month time frame, without any changes occurring independent of the associations between structure and function alone.

Original languageEnglish
Pages (from-to)3714-3722
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Issue number8
Publication statusPublished - Jul 2016
Externally publishedYes


  • Age-related macular degeneration
  • Longitudinal
  • Microperimetry
  • Optical coherence tomography

Cite this