Long-term treatment outcomes of patients with primary optic nerve sheath meningioma treated with stereotactic radiotherapy

Gishan Ratnayake, T. Oh, R. Mehta, Thomas Hardy, Katrina Woodford, Rebecca Haward, Jeremy D. Ruben, Michael J. Dally

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8 Citations (Scopus)

Abstract

We analysed the long-term outcomes of patients with primary optic nerve sheath meningioma (ONSM) treated with stereotactic radiotherapy (SRT). 26 patients with primary ONSM were treated with SRT between 2004 and 2013 at a single institution. SRT was delivered with image guidance to a median dose of 50.4 Gy in 28 fractions. 4 patients had prior surgical debulking. At a median radiological follow-up of 68 months, the MRI based tumour control was 100%. Visual acuity improved in 10 (38.4%), remained stable in 10 (38.4%) and was reduced in 6 (23.1%) patients following treatment. Stable or improved vision post-treatment was seen in 92.3% of patients with good pre-treatment vision (best corrected visual acuity 6/18 or better), compared to only 61.5% of patients with poor pre-treatment vision (best corrected visual acuity 6/24 or worse). Overall, the treatment was well tolerated with no Grade 2 or greater acute toxicity. Minimal other ophthalmic complications were seen with only one patient developing late onset Grade 3 radiation retinopathy.

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalJournal of Clinical Neuroscience
Volume68
DOIs
Publication statusPublished - 1 Oct 2019

Keywords

  • Benign tumour
  • Dose fractionation
  • Optic nerve sheath meningioma
  • Radiosurgery
  • Stereotactic radiotherapy

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