Long-term survival of elderly patients undergoing percutaneous coronary intervention for myocardial infarction complicated by cardiogenic shock

Han S Lim, Nick Andrianopoulos, Hariharan Sugumar, Dion Stub, Angela Leone Brennan, Chris C S Lim, Peter Barlis, William Joseph Van Gaal, Christopher Michael Reid, Kerrie Charter, Martin J Sebastian, Gishel New, Andrew Edward Ajani, Hamid Mohamed Omar Farouque, Stephen Duffy, David J Clark

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Abstract

Background The long-term benefit of early percutaneous coronary intervention (PCI) for cardiogenic shock (CS) in elderly patients remains unclear. We sought to assess the long-term survival of elderly patients (age ? 75 years) with myocardial infarction (MI) complicated by CS undergoing PCI. Methods We analyzed baseline characteristics, early outcomes, and long-term survival in 421 consecutive patients presenting with MI and CS who underwent PCI from the Melbourne Interventional Group registry from 2004 to 2011. Mean follow-up of patients who survived to hospital discharge was 3.0 ? 1.8 years. Results Of the 421 consecutive patients, 122 patients were elderly (? 75 years) and 299 patients were younger (<75 years). The elderly cohort had significantly more females, peripheral and cerebrovascular disease, renal impairment, heart failure (HF) and prior MI (all p <0.05). Procedural success was lower in the elderly (83 vs. 92 , p <0.01). Long-term mortality was significantly higher in the elderly (p <0.01), driven by high in-hospital mortality (48 vs. 36 , p <0.05). However, in a landmark analysis of hospital survivors in the elderly group, long-term mortality rates stabilized, approximating younger patients with CS (p = 0.22). Unsuccessful procedure, renal impairment, HF and diabetes mellitus were independent predictors of long-term mortality. However, age ? 75 was not a significant predictor (HR 1.2; 95 CI 0.9-1.7; p = 0.2). Conclusions Elderly patients with MI and CS have lower procedural success and higher in-hospital mortality compared to younger patients. However, comparable long-term survival can be achieved, especially in patients who survive to hospital discharge with the selective use of early revascularization.
Original languageEnglish
Pages (from-to)259 - 264
Number of pages6
JournalInternational Journal of Cardiology
Volume195
DOIs
Publication statusPublished - 2015

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