Long-term structural and chemical stability of DNA in hydrated ionic liquids

Vijayaraghavan Ranganathan, Alexey Izgorodin, Venkatraman Ganesh, M Surianarayanan, Douglas Macfarlane

Research output: Contribution to journalArticleResearchpeer-review

170 Citations (Scopus)

Abstract

There is much interest in the use of DNA as an advanced material.[1] For example, DNA has been discussed as the a??ultimatea?? material for molecular computing[2] and there is much effort directed towards investigating this application. Recently, DNA has also been employed in templated chemical synthesis, nanomachines, and biosensors.[3a??5] The use of DNA as a biomaterial from a variety of readily available sources has gained importance in recent years, especially for the surface treatment of implanted materials.[6] Since it is rich in phosphate groups it has a strong affinity for bone, and DNA has been modified for use as a bone-guiding scaffold by intercalating antibiotics between the stacked base pairs.[7] The water-insoluble form of DNAalso finds a range of other applications as a biomaterial.
Original languageEnglish
Pages (from-to)1631 - 1633
Number of pages3
JournalAngewandte Chemie - International Edition
Volume49
Issue number9
DOIs
Publication statusPublished - 2010

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