Long-term pacemaker dependency and impact of pacing on mortality following transcatheter aortic valve replacement with the LOTUS valve

Mohammad Alasti, Hashrul Rashid, Karthikeyan Rangasamy, Emily Kotschet, David Adam, Jeff Alison, Robert Gooley, Sarah Zaman

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Objectives: To determine permanent pacemaker (PPM) dependency following transcatheter aortic valve replacement (TAVR) with the Lotus valve system (Boston Scientific), and the impact of PPM implantation on long-term morbidity and mortality. Background: Conduction abnormalities are among the most common complications following TAVR. Limited studies have assessed pacing dependency following TAVR. Methods: Consecutive patients (n = 166) with severe aortic stenosis who underwent TAVR with the Lotus valve system were prospectively recruited from a single-center. PPMs were implanted according to standard clinical criteria. Patients were followed in-hospital and at 1, 3, 6, and 12 months to determine pacemaker dependency and clinical outcomes. Results: Fourteen patients with a pre-existing PPM (8%) were excluded with the remaining 152 patients aged 83.6 ± 5.6 years and 46% male. PPMs were implanted 3.8 ± 4 days post-TAVR in 38/152 patients (25%). Indication for PPM was complete heart block in 29 (76%) of patients. At 30-day and one-year follow up, 57% and 38% of patients were pacemaker dependent, respectively. The mean ventricular pacing percentage decreased in the first three months after PPM implantation and remained relatively stable after that. Conclusion: Only 38% of Lotus recipients who require a PPM following TAVR with the Lotus valve remain pacing dependent at one year.

Original languageEnglish
Pages (from-to)777-782
Number of pages6
JournalCatheterization and Cardiovascular Interventions
Volume92
Issue number4
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • aortic stenosis
  • pacemaker dependency
  • permanent pacemaker
  • transcatheter aortic valve replacement

Cite this

Alasti, Mohammad ; Rashid, Hashrul ; Rangasamy, Karthikeyan ; Kotschet, Emily ; Adam, David ; Alison, Jeff ; Gooley, Robert ; Zaman, Sarah. / Long-term pacemaker dependency and impact of pacing on mortality following transcatheter aortic valve replacement with the LOTUS valve. In: Catheterization and Cardiovascular Interventions. 2018 ; Vol. 92, No. 4. pp. 777-782.
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title = "Long-term pacemaker dependency and impact of pacing on mortality following transcatheter aortic valve replacement with the LOTUS valve",
abstract = "Objectives: To determine permanent pacemaker (PPM) dependency following transcatheter aortic valve replacement (TAVR) with the Lotus™ valve system (Boston Scientific), and the impact of PPM implantation on long-term morbidity and mortality. Background: Conduction abnormalities are among the most common complications following TAVR. Limited studies have assessed pacing dependency following TAVR. Methods: Consecutive patients (n = 166) with severe aortic stenosis who underwent TAVR with the Lotus valve system were prospectively recruited from a single-center. PPMs were implanted according to standard clinical criteria. Patients were followed in-hospital and at 1, 3, 6, and 12 months to determine pacemaker dependency and clinical outcomes. Results: Fourteen patients with a pre-existing PPM (8{\%}) were excluded with the remaining 152 patients aged 83.6 ± 5.6 years and 46{\%} male. PPMs were implanted 3.8 ± 4 days post-TAVR in 38/152 patients (25{\%}). Indication for PPM was complete heart block in 29 (76{\%}) of patients. At 30-day and one-year follow up, 57{\%} and 38{\%} of patients were pacemaker dependent, respectively. The mean ventricular pacing percentage decreased in the first three months after PPM implantation and remained relatively stable after that. Conclusion: Only 38{\%} of Lotus recipients who require a PPM following TAVR with the Lotus valve remain pacing dependent at one year.",
keywords = "aortic stenosis, pacemaker dependency, permanent pacemaker, transcatheter aortic valve replacement",
author = "Mohammad Alasti and Hashrul Rashid and Karthikeyan Rangasamy and Emily Kotschet and David Adam and Jeff Alison and Robert Gooley and Sarah Zaman",
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Long-term pacemaker dependency and impact of pacing on mortality following transcatheter aortic valve replacement with the LOTUS valve. / Alasti, Mohammad; Rashid, Hashrul; Rangasamy, Karthikeyan; Kotschet, Emily; Adam, David; Alison, Jeff; Gooley, Robert; Zaman, Sarah.

In: Catheterization and Cardiovascular Interventions, Vol. 92, No. 4, 01.10.2018, p. 777-782.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Long-term pacemaker dependency and impact of pacing on mortality following transcatheter aortic valve replacement with the LOTUS valve

AU - Alasti, Mohammad

AU - Rashid, Hashrul

AU - Rangasamy, Karthikeyan

AU - Kotschet, Emily

AU - Adam, David

AU - Alison, Jeff

AU - Gooley, Robert

AU - Zaman, Sarah

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Objectives: To determine permanent pacemaker (PPM) dependency following transcatheter aortic valve replacement (TAVR) with the Lotus™ valve system (Boston Scientific), and the impact of PPM implantation on long-term morbidity and mortality. Background: Conduction abnormalities are among the most common complications following TAVR. Limited studies have assessed pacing dependency following TAVR. Methods: Consecutive patients (n = 166) with severe aortic stenosis who underwent TAVR with the Lotus valve system were prospectively recruited from a single-center. PPMs were implanted according to standard clinical criteria. Patients were followed in-hospital and at 1, 3, 6, and 12 months to determine pacemaker dependency and clinical outcomes. Results: Fourteen patients with a pre-existing PPM (8%) were excluded with the remaining 152 patients aged 83.6 ± 5.6 years and 46% male. PPMs were implanted 3.8 ± 4 days post-TAVR in 38/152 patients (25%). Indication for PPM was complete heart block in 29 (76%) of patients. At 30-day and one-year follow up, 57% and 38% of patients were pacemaker dependent, respectively. The mean ventricular pacing percentage decreased in the first three months after PPM implantation and remained relatively stable after that. Conclusion: Only 38% of Lotus recipients who require a PPM following TAVR with the Lotus valve remain pacing dependent at one year.

AB - Objectives: To determine permanent pacemaker (PPM) dependency following transcatheter aortic valve replacement (TAVR) with the Lotus™ valve system (Boston Scientific), and the impact of PPM implantation on long-term morbidity and mortality. Background: Conduction abnormalities are among the most common complications following TAVR. Limited studies have assessed pacing dependency following TAVR. Methods: Consecutive patients (n = 166) with severe aortic stenosis who underwent TAVR with the Lotus valve system were prospectively recruited from a single-center. PPMs were implanted according to standard clinical criteria. Patients were followed in-hospital and at 1, 3, 6, and 12 months to determine pacemaker dependency and clinical outcomes. Results: Fourteen patients with a pre-existing PPM (8%) were excluded with the remaining 152 patients aged 83.6 ± 5.6 years and 46% male. PPMs were implanted 3.8 ± 4 days post-TAVR in 38/152 patients (25%). Indication for PPM was complete heart block in 29 (76%) of patients. At 30-day and one-year follow up, 57% and 38% of patients were pacemaker dependent, respectively. The mean ventricular pacing percentage decreased in the first three months after PPM implantation and remained relatively stable after that. Conclusion: Only 38% of Lotus recipients who require a PPM following TAVR with the Lotus valve remain pacing dependent at one year.

KW - aortic stenosis

KW - pacemaker dependency

KW - permanent pacemaker

KW - transcatheter aortic valve replacement

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DO - 10.1002/ccd.27463

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JF - Catheterization and Cardiovascular Interventions

SN - 1522-1946

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