Long-term pacemaker dependency and impact of pacing on mortality following transcatheter aortic valve replacement with the LOTUS valve

Mohammad Alasti, Hashrul Rashid, Karthikeyan Rangasamy, Emily Kotschet, David Adam, Jeff Alison, Robert Gooley, Sarah Zaman

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10 Citations (Scopus)


Objectives: To determine permanent pacemaker (PPM) dependency following transcatheter aortic valve replacement (TAVR) with the Lotus valve system (Boston Scientific), and the impact of PPM implantation on long-term morbidity and mortality. Background: Conduction abnormalities are among the most common complications following TAVR. Limited studies have assessed pacing dependency following TAVR. Methods: Consecutive patients (n = 166) with severe aortic stenosis who underwent TAVR with the Lotus valve system were prospectively recruited from a single-center. PPMs were implanted according to standard clinical criteria. Patients were followed in-hospital and at 1, 3, 6, and 12 months to determine pacemaker dependency and clinical outcomes. Results: Fourteen patients with a pre-existing PPM (8%) were excluded with the remaining 152 patients aged 83.6 ± 5.6 years and 46% male. PPMs were implanted 3.8 ± 4 days post-TAVR in 38/152 patients (25%). Indication for PPM was complete heart block in 29 (76%) of patients. At 30-day and one-year follow up, 57% and 38% of patients were pacemaker dependent, respectively. The mean ventricular pacing percentage decreased in the first three months after PPM implantation and remained relatively stable after that. Conclusion: Only 38% of Lotus recipients who require a PPM following TAVR with the Lotus valve remain pacing dependent at one year.

Original languageEnglish
Pages (from-to)777-782
Number of pages6
JournalCatheterization and Cardiovascular Interventions
Issue number4
Publication statusPublished - 1 Oct 2018


  • aortic stenosis
  • pacemaker dependency
  • permanent pacemaker
  • transcatheter aortic valve replacement

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