The objective of this study was to evaluate long-term health-related quality of life outcomes among patients who had a colectomy within the previous 10 years. A cross-sectional survey was administered to consecutive patients =18 years of age with ulcerative colitis who had a colectomy within the last 10 years from centers in Canada, Australia, and the United Kingdom. Data were extracted from medical chart reviews to confirm selected self-reported patient characteristics. Of 351 survey respondents, 49 were male and the median age was 40 years (interquartile range 30?52). Respondents were diagnosed with UC a median of 9.2 (5.7?15.1) years prior to the survey and first surgery occurred a median of 3.7 (2.1?5.8) years ago. Although most respondents (84 ) reported improved quality of life compared to the status before surgery, 81 experienced problems in at least one of the following areas: depression, work productivity, restrictions in diet, body image, and sexual function. According to HADS scores, 30 and 17 of survey respondents experienced anxiety and depression, respectively. Among moderate to severe UC patients pre-colectomy, 27 of men and 28 of women reported that their sexual life was worse now than before surgery. The mean EQ-5D utility index score overall was 0.79 (95 confidence interval 0.77?0.81). Quality of life after colectomy for UC is generally good, but there are persistent quality of life issues that impact multiple domains, including psychological and sexual functioning.