Long-term mood, quality of life, and seizure freedom in intracranial EEG epilepsy surgery

Oshi Swarup, Alexandra Waxmann, Jocelyn Chu, Simon Vogrin, Alan Lai, Joshua Laing, James Barker, Linda Seiderer, Sophia Ignatiadis, Chris Plummer, Ross Carne, Udaya Seneviratne, Mark Cook, Michael Murphy, Wendyl D'Souza

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Objectives: To determine the long-term outcomes in patients undergoing intracranial EEG (iEEG) evaluation for epilepsy surgery in terms of seizure freedom, mood, and quality of life at St. Vincent's Hospital, Melbourne. Methods: Patients who underwent iEEG between 1999 and 2016 were identified. Patients were retrospectively assessed between 2014 and 2017 by specialist clinic record review and telephone survey with standardized validated questionnaires for: 1) seizure freedom using the Engel classification; 2) Mood using the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E); 3) Quality-of-life outcomes using the QOLIE-10 questionnaire. Summary statistics and univariate analysis were performed to investigate variables for significance. Results: Seventy one patients underwent iEEG surgery: 49 Subdural, 14 Depths, 8 Combination with 62/68 (91.9%) of those still alive, available at last follow-up by telephone survey or medical record review (median of 8.2 years). The estimated epileptogenic zone was 62% temporal and 38% extra-temporal. At last follow-up, 69.4% (43/62) were Engel Class I and 30.6% (19/62) were Engel Class II-IV. Further, a depressive episode (NDDI-E > 15) was observed in 34% (16/47), while a ‘better quality of life’ (QOLIE-10 score < 25) was noted in 74% (31/42). Quality of life (p < 0.001) but not mood (p = 0.24) was associated with seizure freedom. Significance: Long-term seizure freedom can be observed in patients undergoing complex epilepsy surgery with iEEG evaluation and is associated with good quality of life.

Original languageEnglish
Article number108241
Number of pages8
JournalEpilepsy & Behavior
Volume123
DOIs
Publication statusPublished - Oct 2021
Externally publishedYes

Keywords

  • Epilepsy surgery
  • Intracranial electrode monitoring
  • Long-term
  • Mood
  • Quality of life
  • Seizure freedom

Cite this