TY - JOUR
T1 - Long-term exposure to outdoor light at night and mild cognitive impairment
T2 - A nationwide study in Chinese veterans
AU - Chen, Yan
AU - Tan, Jiping
AU - Liu, Yuewei
AU - Dong, Guang Hui
AU - Yang, Bo Yi
AU - Li, Nan
AU - Wang, Luning
AU - Chen, Gongbo
AU - Li, Shanshan
AU - Guo, Yuming
N1 - Funding Information:
This study was supported by the Basic and Applied Basic Research Project of Guangzhou Municipal Science and Technology Bureau (202102020275), the National Natural Science Foundation of China (81903279), and the Special Research Project on Health Care, Health Sector of the General Logistics Department of Peoples Liberation Army (project numbers: 07BJZ04, 10BJZ19, 11BJZ09, and 12BJZ46).
Publisher Copyright:
© 2022
PY - 2022/11/15
Y1 - 2022/11/15
N2 - Background: Evidence is limited for the association between outdoor light at night (LAN) and mild cognitive impairment (MCI), a transitional stage between normal aging and dementia and Alzheimer's disease in the elderly. In this study, the association between outdoor LAN and MCI was examined based on a multi-city study among veterans in China. Methods: A total of 5496 participants from 18 cities across China were investigated during 2009–2011, selected using a multi-stage random sampling method. Participants' cognitive function was firstly assessed using the Mini Mental State Examination and the Montreal Cognitive Assessment in the Chinese version, and then was further confirmed by clinical examination. Participants' exposure to outdoor LAN was estimated using the Global Radiance Calibrated Nighttime Lights Product at a spatial resolution of around 1 km. The mixed-effects logistic regression model was used to examine the association between outdoor LAN and MCI. Results: After controlling for covariates, odds ratio (OR) and 95 % confidence intervals (95%CI) of MCI was 1.44 (95%CI: 1.36, 1.52) associated with per interquartile range (IQR = 21.17 nW/cm2/sr) increase in exposure to outdoor LAN during the 3 years before the investigation, and for categorical variable of LAN, the highest OR was observed for the highest against the lowest quartile of LAN with a monotonically increasing trend (p values for trend <0.001). Furthermore, higher ORs were observed for females, veterans who had less educational attainment, and had no regular social activities. Conclusions: Our study revealed that exposure to excessive outdoor LAN was associated with higher risk of MCI. Effective measures should be taken to reduce LAN exposure, which may help to prevent MCI.
AB - Background: Evidence is limited for the association between outdoor light at night (LAN) and mild cognitive impairment (MCI), a transitional stage between normal aging and dementia and Alzheimer's disease in the elderly. In this study, the association between outdoor LAN and MCI was examined based on a multi-city study among veterans in China. Methods: A total of 5496 participants from 18 cities across China were investigated during 2009–2011, selected using a multi-stage random sampling method. Participants' cognitive function was firstly assessed using the Mini Mental State Examination and the Montreal Cognitive Assessment in the Chinese version, and then was further confirmed by clinical examination. Participants' exposure to outdoor LAN was estimated using the Global Radiance Calibrated Nighttime Lights Product at a spatial resolution of around 1 km. The mixed-effects logistic regression model was used to examine the association between outdoor LAN and MCI. Results: After controlling for covariates, odds ratio (OR) and 95 % confidence intervals (95%CI) of MCI was 1.44 (95%CI: 1.36, 1.52) associated with per interquartile range (IQR = 21.17 nW/cm2/sr) increase in exposure to outdoor LAN during the 3 years before the investigation, and for categorical variable of LAN, the highest OR was observed for the highest against the lowest quartile of LAN with a monotonically increasing trend (p values for trend <0.001). Furthermore, higher ORs were observed for females, veterans who had less educational attainment, and had no regular social activities. Conclusions: Our study revealed that exposure to excessive outdoor LAN was associated with higher risk of MCI. Effective measures should be taken to reduce LAN exposure, which may help to prevent MCI.
KW - China
KW - Light at night
KW - Mild cognitive impairment
KW - Veteran
UR - http://www.scopus.com/inward/record.url?scp=85134893761&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2022.157441
DO - 10.1016/j.scitotenv.2022.157441
M3 - Article
C2 - 35863567
AN - SCOPUS:85134893761
SN - 0048-9697
VL - 847
JO - Science of the Total Environment
JF - Science of the Total Environment
M1 - 157441
ER -