Long-term evolution and transmission dynamics of swine influenza A virus

Dhanasekaran Vijaykrishna, Gavin J. D. Smith, Oliver G. Pybus, Huachen Zhu, Samir Bhatt, Leo L. M. Poon, Steven Riley, Justin Bahl, Siu K. Ma, Chung L. Cheung, Ranawaka A. P. M. Perera, Honglin Chen, Kennedy F. Shortridge, Richard J. Webby, Robert G. Webster, Yi Guan, J. S. Malik Peiris

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158 Citations (Scopus)

Abstract

Swine influenza A viruses (SwIV) cause significant economic losses in animal husbandry as well as instances of human disease1 and occasionally give rise to human pandemics2, including that caused by the H1N1/2009 virus3,4. The lack of systematic and longitudinal influenza surveillance in pigs has hampered attempts to reconstruct the origins of this pandemic4. Most existing swine data were derived from opportunistic samples collected from diseased pigs in disparate geographical regions, not from prospective studies in defined locations, hence the evolutionary and transmission dynamics of SwIV are poorly understood. Here we quantify the epidemiological, genetic and antigenic dynamics of SwIV in Hong Kong using a data set of more than 650 SwIV isolates and more than 800 swine sera from 12 years of systematic surveillance in this region, supplemented with data stretching back 34 years. Intercontinental virus movement has led to reassortment and lineage replacement, creating an antigenically and genetically diverse virus population whose dynamics are quantitatively different from those previously observed for human influenza viruses. Our findings indicate that increased antigenic drift is associated with reassortment events and offer insights into the emergence of influenza viruses with epidemic potential in swine and humans.

Original languageEnglish
Pages (from-to)519-522
Number of pages4
JournalNature
Volume473
Issue number7348
DOIs
Publication statusPublished - 26 May 2011
Externally publishedYes

Cite this

Vijaykrishna, D., Smith, G. J. D., Pybus, O. G., Zhu, H., Bhatt, S., Poon, L. L. M., Riley, S., Bahl, J., Ma, S. K., Cheung, C. L., Perera, R. A. P. M., Chen, H., Shortridge, K. F., Webby, R. J., Webster, R. G., Guan, Y., & Peiris, J. S. M. (2011). Long-term evolution and transmission dynamics of swine influenza A virus. Nature, 473(7348), 519-522. https://doi.org/10.1038/nature10004