Long-term assessment of oxcarbazepine in a naturalistic setting: A retrospective study

U. Seneviratne, Wendyl D'souza, Mark J Cook

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Background: New antiepileptics seem to be better tolerated by patients. The retention rate of an antiepileptic would be a useful indicator of its practical usefulness. 

Aims: To assess the long-term outcome of oxcarbazepine (OXC) in a naturalistic setting by determining the retention rate. 

Methods: This is a retrospective study. All epilepsy patients treated with OXC at a tertiary care epilepsy center during a period of 3.5 years were included in this study. Retention rates of OXC at 1 and 3 years were estimated for each cohort group using Kaplan-Meier estimates and corresponding 95% confidence intervals. 

Results: A total of 98 patients were studied. OXC was used as monotherapy in 14 (14.3%) and as add-on therapy in 84 (85.7%). The mean daily dose was 947 ± 492 mg and 60% received ≤900 mg/day. Using the Kaplan-Meier survival analysis, the retention rates of OXC at 1 and 3 years were estimated to be 0.853 (0.749-0.956) and 0.737 (0.570-0.904), respectively. 

Conclusions: OXC is well tolerated by patients as both monotherapy and add-on therapy.

Original languageEnglish
Pages (from-to)367-369
Number of pages3
JournalActa Neurologica Scandinavica
Volume117
Issue number5
DOIs
Publication statusPublished - May 2008
Externally publishedYes

Keywords

  • Antiepileptics
  • Epilepsy
  • Oxcarbazepine
  • Retention rate

Cite this