Long-Circulating Au-TiO2 Nanocomposite as a Sonosensitizer for ROS-Mediated Eradication of Cancer

V. G. Deepagan, Dong Gil You, Wooram Um, Hyewon Ko, Seunglee Kwon, Ki Young Choi, Gi Ra Yi, Jun Young Lee, Doo Sung Lee, Kwangmeyung Kim, Ick Chan Kwon, Jae Hyung Park

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114 Citations (Scopus)

Abstract

Although sonodynamic therapy (SDT) has emerged as a potential alternative to conventional photodynamic therapy, the low quantum yield of the sonosensitizer such as TiO2 nanoparticles (NPs) is still a major concern. Here, we have developed hydrophilized Au-TiO2 nanocomposites (HAu-TiO2 NCs) as sonosensitizers for improved SDT. The physicochemical properties of HAu-TiO2 NCs were thoroughly studied and compared with their counterparts without gold deposition. Upon exposure of HAu-TiO2 NCs to ultrasound, a large quantity of reactive oxygen species (ROS) were generated, leading to complete suppression of tumor growth after their systemic administration in vivo. Overall, it was evident that the composites of gold with TiO2 NPs significantly augmented the levels of ROS generation, implying their potential as SDT agents for cancer therapy.

Original languageEnglish
Pages (from-to)6257-6264
Number of pages8
JournalNano Letters
Volume16
Issue number10
DOIs
Publication statusPublished - 12 Oct 2016
Externally publishedYes

Keywords

  • Au-TiO nanocomposite
  • enhanced sonodynamic therapy
  • prolonged circulation
  • ROS
  • ultrasound

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