Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8 + T cell memory

Katherine Kedzierska, John Stambas, Misty R. Jenkins, Rachael Keating, Stephen J. Turner, Peter C. Doherty

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45 Citations (Scopus)

Abstract

The rapid recall of influenza virus-specific CD8 + T cell effector function is protective, although our understanding of T cell memory remains incomplete. Recent debate has focused particularly on the CD62L lymph node homing receptor. The present analysis shows that although functional memory can be established from both CD62L hi and CD62L lo CD8 + T cell subsets soon after initial encounter between naive precursors and antigen, the optimal precursors are CD8 + CD44 hi CD25 lo immune lymphocytes isolated from draining lymph nodes on day 3.5 after influenza virus infection. Analysis of primed T cells at different times after challenge indicates that the capacity to transfer memory is diminished at the peak of the primary cytotoxic T lymphocyte response, challenging speculations that the transition to memory first requires full differentiation to effector status. It seems that location rather than CD62Lhi/lo phenotype may be the more profitable focus for further dissection of the early establishment of T cell memory.

Original languageEnglish
Pages (from-to)9782-9787
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number23
DOIs
Publication statusPublished - 5 Jun 2007
Externally publishedYes

Keywords

  • Draining lymph nodes
  • Generation of memory

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