Localization of the human interferon-induced, ds-RNA activated p68 kinase gene (PRKR) to chromosome 2p21-p22

Jeremy Squire, Eliane F. Meurs, Karen L. Chong, Nigel A.J. McMillan, Ara G. Hovanessian, Bryan R.G. Williams

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24 Citations (Scopus)

Abstract

The interferon-induced dsRNA-activated protein kinase (PRKR) belongs to a subclass of serine/threonine kinases, involved in the regulation of protein synthesis by phosphorylation of the α subunit of initiation factor eIF2. Somatic cell hybrids segregating human chromosomes were used to assign this kinase to human chromosome 2. Fluorescence in situ hybridization confirmed this assignment and further localized the gene (PRKR) to the boundary region of hands p21 and 22.

Original languageEnglish
Pages (from-to)768-770
Number of pages3
JournalGenomics
Volume16
Issue number3
DOIs
Publication statusPublished - Jun 1993
Externally publishedYes

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