Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

Maria Jelinic, Chen Huei Leo, Emiel D Post Uiterweer, Shaun L Sandow, Jonathan H Gooi, Mary E Wlodek, Kirk P Conrad, Helena C Parkington, Marianne Tare, Laura J Parry

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Abstract

Relaxin is a potent vasodilator of small resistance arteries and modifies arterial compliance in some systemic vascular beds, yet receptors for relaxin, such as RXFP1, have only been localized to vascular smooth muscle. This study first aimed to localize RXFP1 in rat arteries and veins from different organ beds and determine whether receptors are present in endothelial cells. We then tested the hypothesis that region-specific vascular effects of relaxin may be influenced by the cellular localization of RXFP1 within different blood vessels. The aorta, vena cava, mesenteric artery, and vein had significantly higher (P
Original languageEnglish
Pages (from-to)275 - 287
Number of pages13
JournalThe FASEB Journal
Volume28
Issue number1
DOIs
Publication statusPublished - 2014

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