Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

Maria Jelinic; Chen Huei Leo; Emiel D Post Uiterweer; Shaun L Sandow; Jonathan H Gooi; Mary E Wlodek; Kirk P Conrad; Helena C Parkington; Marianne Tare; Laura J Parry

doi:10.1096/fj.13-233429

Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

Maria Jelinic, Chen Huei Leo, Emiel D Post Uiterweer, Shaun L Sandow, Jonathan H Gooi, Mary E Wlodek, Kirk P Conrad, Helena C Parkington, Marianne Tare, Laura J Parry

Physiology

Research output: Contribution to journal › Article › Research › peer-review

78 Citations (Scopus)

Abstract

Relaxin is a potent vasodilator of small resistance arteries and modifies arterial compliance in some systemic vascular beds, yet receptors for relaxin, such as RXFP1, have only been localized to vascular smooth muscle. This study first aimed to localize RXFP1 in rat arteries and veins from different organ beds and determine whether receptors are present in endothelial cells. We then tested the hypothesis that region-specific vascular effects of relaxin may be influenced by the cellular localization of RXFP1 within different blood vessels. The aorta, vena cava, mesenteric artery, and vein had significantly higher (P

Original language	English
Pages (from-to)	275 - 287
Number of pages	13
Journal	The FASEB Journal
Volume	28
Issue number	1
DOIs	https://doi.org/10.1096/fj.13-233429
Publication status	Published - 2014

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Jelinic, M., Leo, C. H., Post Uiterweer, E. D., Sandow, S. L., Gooi, J. H., Wlodek, M. E., Conrad, K. P., Parkington, H. C., Tare, M., & Parry, L. J. (2014). Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment. The FASEB Journal, 28(1), 275 - 287. https://doi.org/10.1096/fj.13-233429

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title = "Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment",

abstract = "Relaxin is a potent vasodilator of small resistance arteries and modifies arterial compliance in some systemic vascular beds, yet receptors for relaxin, such as RXFP1, have only been localized to vascular smooth muscle. This study first aimed to localize RXFP1 in rat arteries and veins from different organ beds and determine whether receptors are present in endothelial cells. We then tested the hypothesis that region-specific vascular effects of relaxin may be influenced by the cellular localization of RXFP1 within different blood vessels. The aorta, vena cava, mesenteric artery, and vein had significantly higher (P",

author = "Maria Jelinic and Leo, {Chen Huei} and {Post Uiterweer}, {Emiel D} and Sandow, {Shaun L} and Gooi, {Jonathan H} and Wlodek, {Mary E} and Conrad, {Kirk P} and Parkington, {Helena C} and Marianne Tare and Parry, {Laura J}",

year = "2014",

doi = "10.1096/fj.13-233429",

language = "English",

volume = "28",

pages = "275 -- 287",

journal = "The FASEB Journal",

issn = "0892-6638",

publisher = "Federation of American Society for Experimental Biology",

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Jelinic, M, Leo, CH, Post Uiterweer, ED, Sandow, SL, Gooi, JH, Wlodek, ME, Conrad, KP, Parkington, HC , Tare, M & Parry, LJ 2014, 'Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment', The FASEB Journal, vol. 28, no. 1, pp. 275 - 287. https://doi.org/10.1096/fj.13-233429

Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment. / Jelinic, Maria; Leo, Chen Huei; Post Uiterweer, Emiel D et al.
In: The FASEB Journal, Vol. 28, No. 1, 2014, p. 275 - 287.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

AU - Jelinic, Maria

AU - Leo, Chen Huei

AU - Post Uiterweer, Emiel D

AU - Sandow, Shaun L

AU - Gooi, Jonathan H

AU - Wlodek, Mary E

AU - Conrad, Kirk P

AU - Parkington, Helena C

AU - Tare, Marianne

AU - Parry, Laura J

PY - 2014

Y1 - 2014

N2 - Relaxin is a potent vasodilator of small resistance arteries and modifies arterial compliance in some systemic vascular beds, yet receptors for relaxin, such as RXFP1, have only been localized to vascular smooth muscle. This study first aimed to localize RXFP1 in rat arteries and veins from different organ beds and determine whether receptors are present in endothelial cells. We then tested the hypothesis that region-specific vascular effects of relaxin may be influenced by the cellular localization of RXFP1 within different blood vessels. The aorta, vena cava, mesenteric artery, and vein had significantly higher (P

AB - Relaxin is a potent vasodilator of small resistance arteries and modifies arterial compliance in some systemic vascular beds, yet receptors for relaxin, such as RXFP1, have only been localized to vascular smooth muscle. This study first aimed to localize RXFP1 in rat arteries and veins from different organ beds and determine whether receptors are present in endothelial cells. We then tested the hypothesis that region-specific vascular effects of relaxin may be influenced by the cellular localization of RXFP1 within different blood vessels. The aorta, vena cava, mesenteric artery, and vein had significantly higher (P

UR - http://www.fasebj.org.ezproxy.lib.monash.edu.au/content/28/1/275.full.pdf+html

U2 - 10.1096/fj.13-233429

DO - 10.1096/fj.13-233429

M3 - Article

SN - 0892-6638

VL - 28

SP - 275

EP - 287

JO - The FASEB Journal

JF - The FASEB Journal

IS - 1

ER -

Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

Abstract

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